Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests.

Pemoline may cause some serious side effects, including liver problems. Also, medicines like pemoline, when used for a long time, have been reported to slow the growth rate of children. Some doctors recommend medicine-free periods during treatment with pemoline. Pemoline may also cause unwanted effects on behavior in children with severe mental illness.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:


  1. Dark urine
  2. yellow eyes or skin

Check with your doctor as soon as possible if any of the following side effects occur:


  1. Convulsions (seizures)
  2. hallucinations (seeing, hearing, or feeling things that are not there)
  3. nausea and vomiting
  4. shortness of breath, troubled breathing, wheezing, or tightness in chest
  5. skin rash
  6. sores, ulcers, or white spots on lips or in mouth
  7. swollen or painful glands
  8. uncontrolled movements of eyes, tongue, lips, face, arms, or legs
  9. unusual bleeding or bruising
  10. unusual tiredness
  11. vocal sounds you cannot control

Symptoms of overdose

  1. Agitation
  2. confusion
  3. convulsions (seizures)—may be followed by coma
  4. false sense of well-being
  5. fast heartbeat
  6. hallucinations (seeing, hearing, or feeling things that are not there)
  7. headache (severe)
  8. high blood pressure
  9. high fever
  10. large pupils
  11. muscle trembling or twitching
  12. restlessness
  13. sweating
  14. vomiting

This medicine may also cause the following side effects that your doctor will watch for:


  1. Liver problems
  2. slow growth in children

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Loss of appetite
  2. trouble in sleeping
  3. weight loss

Less common

  1. Dizziness
  2. drowsiness
  3. headache
  4. increased irritability
  5. mental depression
  6. stomachache

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.