Proper Use

Drug information provided by: IBM Micromedex

A nurse or other trained health professional will give you this medicine. You may also be taught how to give your medicine at home. This medicine is given as a shot under your skin (usually in the abdomen, back of the upper arm, or thighs).

If you are injecting peginterferon beta-1a yourself, use it exactly as directed by your doctor. Do not change your dose or dosing schedule without checking first with your doctor. The exact amount of medicine you need has been carefully worked out. Using too much will increase the risk for side effects, while using too little may not improve your condition.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

Do not inject into an area of the body where the skin is irritated, reddened, bruised, infected, or scarred in any way.

Check the injection site after 2 hours for redness, swelling, and tenderness.

Each package of the medicine contains a Medication Guide and a sheet called Instructions for Use. Read this information carefully and make sure you understand:

  • How to prepare the injection.
  • How to use disposable syringes or pen.
  • How to store the syringes or pen.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For multiple sclerosis:
      • Adults—63 micrograms (mcg) injected under the skin on Day 1. Your doctor will increase your dose to 94 mcg after 14 days, reaching the full dose of 125 mcg on Day 29 (after another 14 days). Then, 125 mcg injected under your skin every 14 days.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep this medicine in the refrigerator if you store it at home. Do not freeze. If refrigeration is not available, it may be kept for up to 30 days at room temperature, away from heat and direct light. You may allow the prefilled pens and prefilled syringes to warm to room temperature for 30 minutes before injection. Do not heat in a microwave oven or in hot water.