Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Aredia


Pamidronate injection is used to treat hypercalcemia (too much calcium in the blood) that may occur in patients with some types of cancer. It is also used to treat Paget's disease of bone, multiple myeloma (tumors formed by the cells of the bone marrow), and certain types of bone metastases (the spread of cancer to the bones).

This medicine is to be administered only by or under the supervision of your doctor.

This product is available in the following dosage forms:

  • Solution
  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of pamidronate injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pamidronate injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving pamidronate injection.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Dehydration or
  • Heart disease or
  • Kidney disease or
  • Leukopenia (low number of white blood cells) or
  • Mineral imbalance (e.g., low calcium, magnesium, phosphorus, or potassium in the blood) or
  • Thrombocytopenia (low number of platelets)—Use with caution. May make these conditions worse.
  • Cancer, history of or
  • Dental or tooth problems or
  • Dental procedures or
  • Poor oral hygiene or
  • Surgery (e.g., dental surgery)—May increase risk for severe jaw problems.
  • Parathyroid disease (e.g., hypoparathyroidism) or
  • Thyroid surgery, history of—These conditions may increase your risk of having hypocalcemia (low levels of calcium in the blood).

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in a vein.

Your doctor may also give you vitamins containing Vitamin D and calcium. Tell your doctor if you are unable to take these supplements.

Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems. However, it is also important to not drink too much liquid. Talk to your doctor about the right amount of liquids for you.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For treating hypercalcemia (too much calcium in the blood):
      • Adults—60 to 90 milligrams (mg) in a solution to be injected over 2 to 24 hours into a vein. If your doctor decides that you need additional doses, you will receive the medicine again after at least 7 days have passed.
      • Children—Use and dose must be determined by your doctor .
    • For treating Paget's disease of bone:
      • Adults—30 mg in a solution to be injected over 4 hours into a vein, for 3 consecutive days. Your doctor will decide if you need more than 3 doses.
      • Children—Use and dose must be determined by your doctor .
    • For treating multiple myeloma:
      • Adults—90 mg in a solution to be injected over 4 hours into a vein once per month. Your doctor will decide how long this treatment should continue.
      • Children—Use and dose must be determined by your doctor .
    • For treating bone metastases:
      • Adults—90 mg in a solution to be injected over 2 hours into a vein once every 3 to 4 weeks. Your doctor will decide how long this treatment should continue.
      • Children—Use and dose must be determined by your doctor .


It is important that your doctor check your progress at regular visits after you have received pamidronate injection. If your condition has improved, your progress must still be checked. The results of laboratory tests or the occurrence of certain symptoms will tell your doctor if your condition is coming back and a second treatment is needed.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

For patients using this medicine for hypercalcemia (too much calcium in the blood):

  • Your doctor may want you to follow a low-calcium diet. If you have any questions about this, check with your doctor.

Your doctor will need to know if you have a history of problems with your mouth or teeth (e.g., gum disease). Make sure your doctor knows if you have been treated with a bisphosphonate medicine, such as alendronate (Fosamax®), etidronate (Didronel®), pamidronate (Aredia®), risedronate (Actonel®), or tiludronate (Skelid®) in the past.

You may need to have a dental exam before you start using this medicine.

It is important that you check with your doctor before having any dental procedures or surgeries done while you are receiving pamidronate. Tell your doctor right away if you have jaw tightness, swelling, numbing, or pain or a loose tooth. This could be symptoms of a severe problem of your jaw.

Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor right away if you have severe bone, joint, or muscle pain after receiving this medicine.

This medicine may increase your risk of developing fractures of the thigh bone. This may be more common if you use it for a long time. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Abdominal or stomach cramps
  2. black, tarry stools
  3. bloody in the urine or stools
  4. blurred vision
  5. chest pain
  6. chills
  7. confusion
  8. convulsions (seizures)
  9. decrease in the amount of urine
  10. dizziness
  11. drowsiness
  12. fainting
  13. fast or irregular heartbeat
  14. fever
  15. headache
  16. increased thirst
  17. loss of appetite
  18. muscle pain, cramps, spasms, or twitching
  19. nausea or vomiting
  20. nervousness
  21. noisy, rattling breathing
  22. numbness or tingling in the hands, feet, or lips
  23. pinpoint red spots on the skin
  24. pounding in the ears
  25. shortness of breath
  26. slow or fast heartbeat
  27. swelling of the fingers, hands, feet, or lower legs
  28. trembling
  29. troubled breathing at rest
  30. unusual bleeding or bruising
  31. unusual tiredness or weakness
  32. vomiting of blood or material that looks like coffee grounds
  33. weight gain

Less common

  1. Cough
  2. dilated neck veins
  3. extreme fatigue
  4. irregular breathing
  5. lower back or side pain
  6. painful or difficult urination
  7. pale skin
  8. swelling
  9. ulcers, sores, or white spots in the mouth


  1. Decreased vision
  2. difficulty with swallowing
  3. eye pain or tenderness
  4. eye redness
  5. hives
  6. itching
  7. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  8. sensitivity of the eye to light
  9. skin rash
  10. sweating
  11. tearing of the eye
  12. tightness in the chest

Incidence not known

  1. Bone, joint, or muscle pain, severe and occasionally incapacitating
  2. faintness, or lightheadedness when getting up suddenly from a lying or sitting position

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. belching
  3. bladder pain
  4. bloody or cloudy urine
  5. body aches or pain
  6. bone pain
  7. constipation
  8. cracks in the skin at the corners of mouth
  9. diarrhea
  10. difficult, burning, or painful urination
  11. difficult or labored breathing
  12. difficulty moving
  13. ear congestion
  14. fear
  15. frequent urge to urinate
  16. heartburn
  17. indigestion
  18. joint pain
  19. lack or loss of strength
  20. lower back or side pain
  21. muscle aching, cramping, pains, or stiffness
  22. nasal congestion
  23. nervousness
  24. pain and swelling at the injection site
  25. sensitivity to heat
  26. shivering
  27. sneezing
  28. soreness or redness around the fingernails and toenails
  29. stomach discomfort, upset, or pain
  30. sweating
  31. swollen joints
  32. trouble sleeping
  33. weight loss

Less common

  1. Ammonia-like breath odor
  2. feeling, seeing, or hearing things that are not there
  3. feeling that others are watching you or controlling your behavior
  4. feeling that others can hear your thoughts
  5. feeling unusually cold
  6. swelling or inflammation of the mouth
  7. unusual behavior

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.