Oxycodone (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

1. Chills
2. cold sweats
3. confusion
4. difficult or labored breathing
5. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
6. fever
7. tightness in the chest
8. twitching

Rare

1. Bloating or swelling of the face, arms, hands, lower legs, or feet
2. blood in the urine
3. burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
4. chest pain
5. cough
6. decrease in the frequency of urination
7. decreased urine output
8. difficult or painful urination
9. difficulty in passing urine (dribbling)
10. difficulty with swallowing
11. dizziness
12. dry mouth
13. fainting
14. fast, irregular, pounding, or racing heartbeat or pulse
15. feeling of warmth or heat
16. flushing or redness of the skin, especially on the face and neck
17. frequent urination
18. headache
19. hives, itching, or skin rash
20. increase in heart rate
21. increased thirst
22. increased volume of pale, dilute urine
23. lightheadedness
24. muscle pain or cramps
25. nausea
26. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
27. rapid breathing
28. rapid weight gain
29. seizures
30. severe constipation
31. severe vomiting
32. stomach pain
33. sunken eyes
34. sweating
35. swollen, painful, or tender lymph glands in the neck, armpit, or groin
36. thirst
37. trembling or shaking of the hands or feet
38. unusual tiredness or weakness
39. unusual weight gain or loss
40. vomiting
41. wrinkled skin

Incidence not known

1. Blurred vision
2. choking
3. clay-colored stools
4. cold, clammy skin
5. dark urine
6. darkening of the skin
7. diarrhea
8. fast, weak pulse
9. gagging
10. irregular, fast, slow, or shallow breathing
11. loss of appetite
12. loss of consciousness
13. pale or blue lips, fingernails, or skin
14. unpleasant breath odor
15. very slow heartbeat
16. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

1. Change in consciousness
2. chest pain or discomfort
3. cold, clammy skin
4. constricted, pinpoint, or small pupils (black part of the eye)
5. coughing that sometimes produces a pink frothy sputum
6. decreased awareness or responsiveness
7. increased sweating
8. irregular, fast, or slow, or shallow breathing
9. loss of consciousness
10. no muscle tone or movement
11. pale or blue lips, fingernails, or skin
12. sleepiness or unusual drowsiness
13. slow or irregular heartbeat
14. swelling in the legs and ankles,

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Difficulty having a bowel movement
2. drowsiness
3. lack or loss of strength
4. relaxed and calm feeling

Less common

1. Abnormal dreams
2. anxiety
3. belching
4. burning feeling in the chest or stomach
5. false or unusual sense of well-being
6. heartburn
7. hiccups
8. indigestion
9. stomach discomfort or upset
10. tenderness in the stomach area
11. trouble sleeping
12. weight loss

Rare

1. Absent, missed, or irregular menstrual periods
2. bad, unusual or unpleasant (after) taste
3. bloated or full feeling
4. body aches or pain
5. change in taste
6. change in walking and balance
7. changes in vision
8. clumsiness or unsteadiness
9. continuous ringing or buzzing or other unexplained noise in the ears
10. crying
11. decreased interest in sexual intercourse
12. deep or fast breathing with dizziness
13. delusions of persecution, mistrust, suspiciousness, or combativeness
14. dental caries or tooth decay
15. depression
16. difficulty with speaking
17. dry skin
18. dryness or soreness of the throat
19. excess air or gas in the stomach or bowels
20. excessive muscle tone
21. feeling of constant movement of self or surroundings
22. feeling of unreality
23. general feeling of discomfort or illness
24. headache, severe and throbbing
25. hearing loss
26. hoarseness
27. inability to have or keep an erection
28. increase in body movements
29. increased appetite
30. increased cough
31. irritability
32. loss in sexual ability, desire, drive, or performance
33. loss of heat from the body
34. loss of memory
35. loss of strength or energy
36. muscle stiffness, tension, tightness, pain, or weakness
37. neck pain
38. numbness of the feet, hands, and around the mouth
39. passing of gas
40. problems with memory
41. quick to react or overreact emotionally
42. rapidly changing moods
43. red, swollen skin
44. restlessness
45. runny nose
46. scaly skin
47. sensation of spinning
48. sense of detachment from self or body
49. swelling or inflammation of the mouth
50. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: Sept. 01, 2023