Drug information provided by: IBM Micromedex

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Osilodrostat lowers the cortisol levels (hypocortisolism) in the body, which could lead to adrenal insufficiency, hypertension (low blood pressure), electrolyte imbalance, or hypoglycemia (low blood sugar levels). Cortisol is lowered further during an infection or physical stress. Check with your doctor right away if you have nausea, vomiting, unusual tiredness or weakness, stomach pain, loss of appetite, or dizziness.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation.

Osilodrostat may cause hypokalemia (low potassium levels in the blood), edema (swelling), or worsen hypertension (high blood pressure). Your doctor may give you a medicine, supplement, or salt substitute the contains potassium to correct your potassium levels. Check with your doctor right away if you have seizures, decreased urine, dry mouth, irregular heartbeat, increased thirst, loss of appetite, mood changes, muscle pain or cramps, nausea, vomiting, numbness or tingling in the hands, feet, or lips, trouble with breathing, unusual tiredness or weakness, swelling in the arms or legs, blurred vision, dizziness, headache, or pounding in the ears.

This medicine may cause acne and increased hair growth on the face, back, arms, and legs in female patients. Talk to your doctor if you have concerns about this.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.