Proper Use

Drug information provided by: Merative, Micromedex®

A home health caregiver or a family member will give you or your child this medicine. It is given as a shot under your skin or into a muscle.

This medicine should be given immediately upon when a suspected or known overdose of an opioid has occurred. This will help prevent serious breathing problems and severe sleepiness that can lead to death.

This medicine comes with patient instructions and a training device. Let your home health caregiver or family member read and follow the directions carefully. Ask your doctor if you have any questions.

To use:

  • Evzio® is available in 2 dosage strengths: 0.4 milligram (mg)/0.4 milliliter (mL) autoinjector or 2 mg/0.4 mL autoinjector. Zimhi™ is available in 5 mg/0.5 mL prefilled syringe.
  • It contains printed instructions on the device label. Evzio® also contains a speaker that provides electronic instructions which guides the user through each step of the injection.
  • Inject the medicine into the outer thighs, through clothing, if needed. If you are giving this medicine to a child younger than 1 year of age, you should pinch the thigh muscle while giving the medicine.
  • Do not use the medicine if it is cloudy, discolored, or has large particles in it.
  • This medicine can only be used one time. Do not remove the safety guard until you are ready to use it.
  • After giving the first dose to the patient, get emergency medical help right away.
  • Closely watch the patient for signs and symptoms of opioid emergency may return after several minutes.
  • Give a new naloxone injection every 2 to 3 minutes if symptoms returned and monitor the patient until emergency medical assistance becomes available.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For opioid overdose:
    • For injection dosage form (Evzio® autoinjector):
      • Adults and children—0.4 or 2 milligrams (mg) injected under the skin or into a muscle.
    • For injection dosage form (Zimhi™ prefilled syringe):
      • Adults and children—5 milligrams (mg) injected under the skin or into a muscle.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.