Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Merrem IV


Meropenem injection is used to treat infections caused by bacteria. It works by killing the bacteria or preventing their growth. This medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of meropenem injection in children 3 months of age and older with complicated skin and skin structure infections and bacterial meningitis, and for children with intra-abdominal infections.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of meropenem injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving meropenem injection.


Information about this meropenem-intravenous-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cholera Vaccine, Live
  • Valproic Acid

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Probenecid

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to penicillins, cephalosporins, or other allergens, history of—Use may increase the risk for an allergic reaction to reoccur.
  • Brain infection (eg, meningitis) caused by bacteria or
  • Brain lesion (eg, tumor) or
  • Seizures, history of—May cause side effects to become worse.
  • Kidney disease—Use with caution. The effects of may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 15 to 30 minutes.


It is very important that your doctor check you or your child closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Meropenem may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you or your child have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive this medicine.

Some patients may develop tremors or seizures while receiving this medicine. If you or your child already have a history of seizures and you are taking anticonvulsants, you should continue unless otherwise directed by your doctor. Tell your doctor if you are taking divalproex sodium (Depakote®) or valproic acid (Depakene®).

Meropenem may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

This medicine may cause seizures, headaches, numbness or tingling sensation. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless thy have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Redness and swelling at the injection site

Less common

  1. Bluish lips or skin
  2. chills
  3. cold, clammy skin
  4. confusion
  5. dizziness
  6. fainting
  7. fast heartbeat
  8. fast, weak pulse
  9. fever
  10. itching skin
  11. lightheadedness
  12. not breathing
  13. pain at the injection site
  14. rapid, shallow breathing
  15. skin rash and itching
  16. sweating


  1. Abdominal or stomach cramps and severe pain
  2. agitation
  3. black, bloody, or tarry stools
  4. black, bloody vomit
  5. bloating or swelling of the face, arms, hands, lower legs, or feet
  6. blurred vision
  7. burning while urinating
  8. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  9. convulsions (seizures)
  10. cough
  11. dark urine
  12. decreased urine output
  13. depression
  14. diarrhea (watery and severe), which may also be bloody
  15. difficult or painful urination
  16. difficulty with breathing
  17. dilated neck veins
  18. extreme fatigue
  19. fever with or without chills
  20. headache
  21. hostility
  22. irregular breathing
  23. irritability
  24. lethargy
  25. light-colored stools
  26. loss of consciousness
  27. muscle twitching
  28. nausea
  29. no blood pressure or pulse
  30. nosebleed
  31. pale skin
  32. pounding in the ears
  33. rapid weight gain
  34. severe constipation
  35. severe vomiting
  36. slow, irregular heartbeat
  37. stopping of the heart
  38. stupor
  39. tightness in the chest
  40. troubled breathing with exertion
  41. unconsciousness
  42. unpleasant breath odor
  43. unusual bleeding or bruising
  44. unusual tiredness or weakness
  45. unusual weight gain or loss
  46. vomiting of blood or material that looks like coffee grounds
  47. weight gain
  48. yellow eyes or skin

Incidence not known

  1. Back, leg, or stomach pains
  2. bleeding gums
  3. blistering, peeling, or loosening of the skin
  4. chest pain
  5. cough or hoarseness
  6. general body swelling
  7. general feeling of tiredness or weakness
  8. joint or muscle pain
  9. large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or sex organs
  10. loss of appetite
  11. lower back or side pain
  12. red skin lesions, often with a purple center
  13. red, irritated eyes
  14. sore throat
  15. sores, ulcers, or white spots in the mouth or on the lips
  16. swollen glands

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Constipation

Less common

  1. Body aches or pain
  2. cold hands and feet
  3. cold sweats
  4. congestion
  5. cool pale skin
  6. dryness or soreness of the throat
  7. increased hunger
  8. indigestion
  9. nightmares
  10. passing of gas
  11. redness, swelling, or soreness of the tongue
  12. runny nose
  13. shakiness
  14. slurred speech
  15. sneezing
  16. stomach pain, fullness, or discomfort
  17. trouble swallowing
  18. vaginal yeast infection
  19. voice changes


  1. Acid or sour stomach
  2. belching
  3. excess air or gas in the stomach or intestines
  4. full feeling
  5. heartburn
  6. hives or welts
  7. redness of the skin
  8. seeing, hearing, or feeling things that are not there
  9. sleepiness or unusual drowsiness
  10. trouble sleeping
  11. white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.