Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Selzentry


Maraviroc is used in combination with other medicines, in the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). This medicine is usually given to patients who have received HIV treatment in the past.

Maraviroc will not cure or prevent HIV infection or AIDS. It helps keep the HIV virus from reproducing, and appears to slow down the destruction of the immune system. This may help delay the development of problems that usually result from AIDS or HIV disease. Maraviroc will not keep you from spreading HIV to other people. People who receive this medicine may continue to have some of the problems usually related to AIDS or HIV disease.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Solution
  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of maraviroc in children younger than 2 years of age. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of maraviroc in the elderly. However, elderly patients are more likely to have age-related liver or kidney problems, which may require caution in patients receiving maraviroc.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Atazanavir
  • Boceprevir
  • Carbamazepine
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Darunavir
  • Delavirdine
  • Efavirenz
  • Enzalutamide
  • Etravirine
  • Fosamprenavir
  • Fosphenytoin
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lopinavir
  • Nefazodone
  • Nelfinavir
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Rifampin
  • Ritonavir
  • Saquinavir
  • St John's Wort
  • Telaprevir
  • Telithromycin
  • Voriconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ceritinib
  • Duvelisib
  • Fosnetupitant
  • Ivosidenib
  • Larotrectinib
  • Lasmiditan
  • Lefamulin
  • Lorlatinib
  • Lumacaftor
  • Netupitant
  • Pexidartinib
  • Venetoclax

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Heart disease or
  • Liver problems (eg, hepatitis B or C), history of or
  • Postural hypotension (low blood pressure after standing up quickly), history of—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Kidney disease, severe (may require dialysis) and also taking certain medicines—Should not be used in patients with this condition.

Proper Use

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

It is important to take this medicine together with other medicines for HIV. Your dose will be based on the other medicines you are taking. Be sure to take all of the medicines your doctor ordered, and to take them at the right times.

Keep taking this medicine for the full time of treatment, even if you begin to feel better.

This medicine works best when there is a constant amount in the blood. To help do this, do not miss any doses. If you need help in planning the best times to take your medicine, check with your doctor.

Do not change your dose or stop taking this medicine without checking with your doctor first. When your supply of this medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of this medicine.

Swallow the tablet whole. Do not break, crush, or chew it.

Measure the oral liquid with an oral dosing syringe and press-in bottle adapter. The average household teaspoon may not hold the right amount of liquid.

You may take this medicine with or without food.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (solution or tablets):
    • For treatment of HIV infection:
      • Adults—150, 300, or 600 milligrams (mg) two times a day, taken together with other medicines. Your doctor may adjust the dose as needed.
      • Children 2 years of age and older weighing at least 10 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is usually 50 to 150 mg (2.5 to 7.5 mL) two times a day, taken together with other medicines. Your doctor may adjust the dose as needed.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If your next regular dose is less than 6 hours away, skip the missed dose and go back to your regular dosing schedule.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.


It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis. Autoimmune disorders such as Graves' disease, polymyositis, and Guillain-Barré syndrome may also occur.

This medicine may cause some people to become dizzy. If this happens, do not drive, use machines, or do anything else that could be dangerous if you are dizzy. You may also feel lightheaded when getting up suddenly from a lying or sitting position, so stand up slowly.

Liver problems with allergic reactions may occur while you are using this medicine. Check with your doctor right away if you have a skin rash with fever, dark-colored urine, pain in the upper right stomach area, vomiting, or yellow eyes or skin.

Serious allergic and skin reactions may occur while using this medicine. These could be life-threatening and require immediate medical attention. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, joint or muscle aches, sores or ulcers on the skin, or fever or chills while you are using this medicine.

Using this medicine may increase your risk of getting infections or cancer. Talk to your doctor if you have concerns about this risk.

This medicine will not keep you from giving HIV to your partner during sex. Make sure you understand and practice safe sex, even if your partner also has HIV, by using a latex condom or other barrier method. This medicine will also not keep you from giving HIV to other people if they are exposed to your blood. Do not re-use or share needles with anyone.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Body aches or pain
  2. burning or stinging of the skin
  3. chills
  4. cough producing mucus
  5. coughing
  6. difficulty with breathing
  7. dizziness when getting up suddenly from a lying or sitting position
  8. ear congestion
  9. headache
  10. loss of voice
  11. pain or tenderness around the eyes and cheekbones
  12. painful blisters on the trunk of the body
  13. painful cold sores or blisters on the lips, nose, eyes, or genitals
  14. sneezing
  15. sore throat
  16. stuffy or runny nose
  17. tightness of the chest
  18. troubled breathing
  19. unusual tiredness or weakness

Less common

  1. Abdominal or stomach pain or tenderness
  2. arm, back, or jaw pain
  3. black, tarry stools
  4. blood in the urine
  5. blurred or double vision
  6. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  7. burning, dry, or itching eyes
  8. burning, itching, and pain in the hairy areas, pus at the root of the hair
  9. change in consciousness
  10. chest pain, discomfort, or heaviness
  11. choking
  12. clay-colored stools
  13. cold, clammy skin
  14. confusion
  15. convulsions
  16. dark-colored urine
  17. diarrhea
  18. dilated neck veins
  19. discharge or excessive tearing
  20. dizziness
  21. drowsiness
  22. earache
  23. extreme fatigue
  24. eye pain
  25. fast, weak pulse
  26. fever
  27. frequent urge to urinate
  28. general feeling of discomfort or illness
  29. general feeling of tiredness or weakness
  30. heavy jaw feeling
  31. inability to speak
  32. increased frequency of urination
  33. irregular breathing
  34. itching or rash
  35. joint pain
  36. light-colored stools
  37. lightheadedness
  38. loosening of a tooth
  39. loss of appetite
  40. loss of bladder control
  41. loss of taste
  42. lumps in the tongue
  43. muscle aches, pains, or stiffness
  44. muscle cramps or spasms
  45. nausea or vomiting
  46. nervousness
  47. noisy breathing
  48. pain or burning during urination
  49. pain or discomfort in the arms, jaw, back, or neck
  50. pain, swelling, or numbness in the mouth or jaw
  51. pale skin
  52. pounding in the ears
  53. redness or swelling in the ear
  54. redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  55. sensitivity of the eye to light
  56. severe abdominal or stomach cramps and pain
  57. severe or sudden headache
  58. shakiness in the legs, arms, hands, or feet
  59. shivering
  60. skin lumps
  61. slow, fast, or irregular heartbeat
  62. slurred speech
  63. spread of cancer to the liver
  64. stiff neck or back
  65. stomach lumps
  66. stomach pain, continuing
  67. sudden loss of consciousness
  68. sweating
  69. swelling of the face, fingers, feet, or lower legs
  70. swollen glands
  71. tearing
  72. temporary blindness
  73. trembling or shaking of the hands or feet
  74. trouble sleeping
  75. troubled breathing with exertion
  76. unable to speak
  77. unpleasant breath odor
  78. unsteadiness or awkwardness
  79. unusual bleeding or bruising
  80. vomiting of blood
  81. warts on the genital area
  82. watery and severe diarrhea, which may also be bloody
  83. weakness in the arms, hands, legs, or feet
  84. weakness on one side of the body, sudden and severe
  85. weight gain
  86. weight loss
  87. yellow eyes or skin

Incidence not known

  1. Blistering, peeling, or loosening of the skin
  2. cough
  3. muscle pain
  4. red skin lesions, often with a purple center
  5. red, irritated eyes
  6. sores, ulcers, or white spots in the mouth or on the lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Difficulty having a bowel movement (stool)
  2. difficulty with moving
  3. increased or decreased appetite
  4. swelling or redness in the joints

Less common

  1. Acid or sour stomach
  2. belching
  3. blistering, crusting, irritation, or reddening of the skin
  4. canker sores
  5. discouragement
  6. feeling sad or empty
  7. flushing or redness of the skin
  8. heartburn
  9. indigestion
  10. irritability
  11. loss of interest or pleasure
  12. redistribution or accumulation of body fat
  13. skin rash, encrusted, scaly, and oozing
  14. sores, ulcers, or white spots on the lips or tongue or inside the mouth
  15. stomach discomfort or upset
  16. tiredness
  17. trouble in concentrating
  18. unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.