Itraconazole (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Decreased urine output
2. dry mouth
3. fever
4. increased thirst
5. irregular heartbeat
6. loss of appetite
7. mood changes
8. muscle pain or cramps
9. nausea
10. numbness or tingling in the hands, feet, or lips
11. seizures
12. trouble breathing
13. unusual tiredness or weakness
14. vomiting

Less common

1. Blurred vision
2. chest pain
3. chills
4. clay-colored stools
5. cloudy urine
6. cold sweats
7. confusion
8. cough
9. dark urine
10. decrease in urine-concentrating ability
11. diarrhea
12. dizziness
13. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
14. drowsiness
15. feeling unusually cold
16. headache
17. itching, skin rash
18. light-colored stools
19. mental changes
20. muscle cramps in the hands, arms, feet, legs, or face
21. muscle spasms (tetany) or twitching
22. nervousness
23. noisy, rattling breathing
24. numbness and tingling around the mouth or fingertips
25. pounding in the ears
26. shivering
27. slow, fast, or pounding heartbeat or pulse
28. sneezing
29. sore throat
30. stomach cramps or pain
31. sweating
32. swelling of the fingers, hands, feet, or lower legs
33. tightness in the chest
34. trembling
35. trouble breathing at rest
36. unpleasant breath odor
37. vomiting of blood
38. weight gain
39. yellow eyes or skin

Rare

1. Black, tarry stools
2. bleeding gums
3. blistering, peeling, or loosening of the skin
4. bloating or swelling of the face, arms, hands, lower legs, or feet
5. blood in the urine or stools
6. blue lips and fingernails
7. burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
8. continuing ringing or buzzing or other unexplained noise in the ears
9. coughing that sometimes produces a pink frothy sputum
10. cracks in the skin
11. decreased appetite
12. difficulty with swallowing
13. dilated neck veins
14. disturbed color perception
15. double vision
16. extreme tiredness or weakness
17. fast or irregular breathing
18. feeling of discomfort
19. general feeling of tiredness or weakness
20. halos around lights
21. hearing loss
22. hives or welts
23. inflammation of the joints
24. joint pain
25. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
26. loss of heat from the body
27. loss of vision
28. lower back or side pain
29. night blindness
30. overbright appearance of lights
31. painful or difficult urination
32. pale skin
33. pinpoint red spots on the skin
34. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
35. rapid weight gain
36. red skin lesions, often with a purple center
37. red, irritated eyes
38. red, swollen skin
39. scaly skin
40. sores, ulcers, or white spots on the lips or in the mouth
41. stomach pain, continuing
42. stomach tenderness
43. swollen lymph glands
44. tunnel vision
45. unsteadiness or awkwardness
46. unusual bleeding or bruising
47. unusual weight gain or loss
48. upper right abdominal or stomach pain
49. weakness in the arms, hands, legs, or feet

Incidence not known

1. Bloating
2. constipation
3. difficult, fast, noisy breathing
4. indigestion
5. loss of bladder control
6. pains in the stomach, side, or abdomen, possibly radiating to the back

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

1. Decreased interest in sexual intercourse
2. difficulty having a bowel movement
3. difficulty with moving
4. discouragement
5. feeling of constant movement of self or surroundings
6. feeling sad or empty
7. inability to have or keep an erection
8. irritability
9. loss in sexual ability, desire, drive, or performance
10. loss of interest or pleasure
11. muscle aching or stiffness
12. pain or tenderness around the eyes and cheekbones
13. passing of gas
14. sensation of spinning
15. sleepiness or unusual drowsiness
16. soreness of the skin
17. stomach fullness or discomfort
18. stuffy or runny nose
19. trouble concentrating
20. trouble sleeping

Rare

1. Belching
2. change in taste
3. hair loss or thinning of the hair
4. heartburn
5. increased need to urinate
6. increased sensitivity of the eyes or skin to sunlight
7. loss of taste
8. menstrual changes
9. passing urine more often
10. redness or other discoloration of the skin
11. severe sunburn

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: Sept. 01, 2024

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