Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Bone or joint pain
  2. burning, redness, itching, or other signs of eye inflammation
  3. difficulty with moving
  4. nosebleeds
  5. scaling, redness, burning, pain, or other signs of inflammation of the lips
  6. skin infection or rash


  1. Attempts at suicide or thoughts of suicide (usually stops after medicine is stopped)
  2. back pain
  3. bleeding or inflammation of the gums
  4. blurred vision or other changes in vision
  5. changes in behavior
  6. decreased vision after sunset or before sunrise (sudden or may continue after medicine is stopped)
  7. diarrhea (severe)
  8. headache (severe or continuing)
  9. mental depression
  10. nausea
  11. pain or tenderness of the eyes
  12. pain, tenderness, or stiffness in the muscles (long-term treatment)
  13. rectal bleeding
  14. stomach pain (severe)
  15. vomiting
  16. yellow eyes or skin

Incidence not known

  1. Black, tarry stools
  2. blistering, peeling, or loosening of the skin
  3. bloating
  4. bloody cough
  5. bloody or cloudy urine
  6. bone tenderness or aching
  7. burning or stinging of the skin
  8. chest pain or tightness
  9. confusion
  10. constipation
  11. continuing ringing or buzzing, or other unexplained noise in the ears
  12. cough
  13. dark-colored urine
  14. decrease in height
  15. difficulty breathing
  16. difficulty speaking
  17. difficulty swallowing
  18. discharge from the eyes
  19. dizziness
  20. double vision
  21. ear pain
  22. excessive tearing
  23. fainting
  24. fast, irregular, pounding, or racing heartbeat or pulse
  25. fever with or without chills
  26. fractures or delayed healing
  27. heartburn
  28. high blood pressure
  29. hives, itching, or skin rash
  30. hoarseness
  31. inability to move the arms, legs, or facial muscles
  32. inability to speak
  33. indigestion
  34. inflamed tissue from infection
  35. irregular yellow patch or lump on the skin
  36. irritation
  37. joint redness, stiffness, or swelling
  38. lack or slowing of normal growth in children
  39. loosening of the fingernails
  40. loss of appetite
  41. loss of bladder control
  42. loss or change in hearing
  43. muscle cramps, pain, spasms, or weakness
  44. pain in the ribs, arms, or legs
  45. pain or burning in the throat
  46. pain or tenderness around the eyes and cheekbones
  47. painful cold sores or blisters on the lips, nose, eyes, or genitals
  48. painful or difficult urination
  49. pains in the chest, groin, or legs, especially calves of the legs
  50. pains in the stomach, side, or abdomen, possibly radiating to the back
  51. pale skin
  52. pinpoint red spots on the skin
  53. red irritated eyes
  54. red skin lesions, often with a purple center
  55. redness or soreness around the fingernails
  56. redness, soreness, or itching skin
  57. seizures
  58. sensitivity of the eyes to sunlight
  59. sneezing
  60. sore throat
  61. sores, ulcers, or white spots on the lips or tongue or inside the mouth
  62. stuffy or runny nose
  63. sudden loss of consciousness
  64. sudden loss of coordination
  65. sudden onset of severe acne on the chest and trunk
  66. sudden onset of slurred speech
  67. swelling of the eyelids, face, lips, hands, lower legs, or feet
  68. swollen, painful or tender lymph glands in the neck, armpit, or groin
  69. unusual bleeding or bruising
  70. unusual tiredness or weakness
  71. unusual weight gain or loss
  72. use of extreme physical or emotional force
  73. watery or bloody diarrhea

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Crusting of the skin
  2. difficulty in wearing contact lenses (may continue after medicine is stopped)
  3. dryness of the eyes (may continue after treatment is stopped)
  4. dryness of the mouth or nose
  5. dryness or itching of the skin
  6. headache (mild)
  7. increased sensitivity of the skin to sunlight
  8. peeling of the skin on palms of the hands or soles of the feet
  9. stomach upset
  10. thinning of the hair (may continue after treatment is stopped)

Incidence not known

  1. Abnormal menstruation
  2. burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
  3. changes in fingernails or toenails
  4. dandruff
  5. darkening of the skin
  6. hair abnormalities
  7. hair loss
  8. increased hair growth, especially on the face
  9. lightening of normal skin color
  10. lightening of treated areas of dark skin
  11. nervousness
  12. oily skin
  13. redness of the face
  14. severe sunburn
  15. skin rash, encrusted, scaly and oozing
  16. stomach burning
  17. sweating
  18. trouble sleeping
  19. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  20. unusually warm skin of the face
  21. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.