Proper Use

Drug information provided by: IBM Micromedex

A nurse or other trained health professional will give you this medicine. It is given as a shot under your skin, usually in the stomach, thighs, or upper arms.

This medicine comes with a patient information leaflet and patient instructions. Read instructions before starting this medicine and with each refill. New information may be given. Follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Evolocumab injection may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor will teach you how to prepare and inject the medicine. Be sure that you understand exactly how to use the medicine.

This medicine comes in 3 forms: a single-dose prefilled pen (autoinjector), single-dose prefilled syringe, and a single-use Pushtronex® system (on-body infusor with prefilled cartridge). Your doctor will prescribe the type and dose that is right for you.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections.

Do not inject on skin areas that are bruised, hard, red, or tender or have cuts, scrapes, infection, scars, or stretch marks.

If you are receiving the 420 milligrams (mg) dose of Repatha®, it can be given: over 5 minutes by using the single-use Pushtronex® system, or by 3 injections consecutively within 30 minutes using the single use prefilled syringe or autoinjector.

The autoinjector pen or prefilled syringe should be removed from the refrigerator and be allowed to reach room temperature for at least 30 minutes before using, or for at least 45 minutes for single-use Pushtronex® system. Do not shake the medicine.

Use each autoinjector pen or syringe only one time. Do not save an open pen or syringe. If the medicine in the pen or syringe has changed color, or if you see particles in it, do not use it.

In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Carefully follow your doctor's order about any special diet.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For primary hyperlipidemia:
      • Adults and children 10 years of age and older—140 milligrams (mg) injected under your skin every 2 weeks, or 420 mg injected under your skin once a month.
      • Children younger than 10 years of age—Use and dose must be determined by your doctor.
    • For homozygous familial hypercholesterolemia:
      • Adults and children 10 years of age and older—420 milligrams (mg) injected under your skin once a month. Your doctor may adjust your dose as needed.
      • Children younger than 10 years of age—Use and dose must be determined by your doctor.
    • To reduce the risk of heart attack, stroke, and heart surgery:
      • Adults—140 milligrams (mg) injected under your skin every 2 weeks, or 420 mg injected under your skin once a month.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

If it is less than 7 days from your missed dose: Inject the dose and resume your original schedule.

If it is more than 7 days from your missed dose and you are using an every-2-week-dose: Wait until your next dose on the original schedule.

If it is more than 7 days from your missed dose and you are using a once-a-month-dose: Inject the dose and start a new schedule using this date.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also keep the medicine in the original carton at room temperature for up to 30 days. Throw away any unused medicine within 30 days.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

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