Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Bone pain or tenderness (increased, continuing, or returning—in patients with Paget's disease)

Less common

  1. Bone fractures, especially of the thigh bone


  1. Abdominal or stomach pain or burning
  2. bloody, black, or tarry stools
  3. chest pain
  4. chills
  5. cough or hoarseness
  6. fever
  7. general feeling of tiredness or weakness
  8. hives
  9. lower back or side pain
  10. noisy breathing
  11. painful or difficult urination
  12. pale skin
  13. skin rash or itching
  14. sore throat
  15. sores, ulcers, or white spots on the lips or inside the mouth
  16. swelling of the arms, legs, face, lips, tongue, or throat
  17. swollen glands
  18. tightness in the chest
  19. unusual bleeding or bruising

Incidence not known

  1. Blistering, peeling, loosening of the skin
  2. bone, joint, or muscle pain that is severe and occasionally disabling
  3. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  4. difficulty in moving
  5. difficulty in swallowing
  6. discouragement
  7. feeling sad or empty
  8. heartburn
  9. heavy jaw feeling
  10. irritability
  11. lack of appetite
  12. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  13. loosening of a tooth
  14. loss of interest or pleasure
  15. loss of memory
  16. pain or burning in the throat
  17. pain, swelling, or numbness in the mouth or jaw
  18. problems with memory
  19. rash with flat lesions or small raised lesions on the skin
  20. red irritated eyes
  21. red skin lesions, often with a purple center
  22. redness or discoloration of the skin
  23. seeing, hearing, or feeling things that are not there
  24. trouble concentrating
  25. trouble sleeping
  26. unusual tiredness or weakness
  27. vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Abdominal or stomach cramps
  2. confusion
  3. convulsions
  4. difficulty in breathing
  5. irregular heartbeats
  6. mood or mental changes
  7. muscle cramps in the hands, arms, feet, legs, or face
  8. numbness and tingling around the mouth, fingertips, or feet
  9. shortness of breath
  10. tremor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Diarrhea
  2. nausea

Incidence not known

  1. Burning feeling in the chest or stomach
  2. hair loss, thinning of hair
  3. headache
  4. indigestion
  5. leg cramps
  6. stomach upset
  7. tenderness in the stomach area

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.