Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Ethiodol


Ethiodized oil injection is an oil-based radiopaque contrast agent. Contrast agents are used to help create a clear picture of the body during different medical procedures. These include:

  • Hysterosalpingography (x-ray test that looks inside the uterus and fallopian tubes) in adults
  • Lymphography (x-ray test that looks at the lymph vessels of the feet or hands) in adults and children
  • Imaging of liver tumors in adults.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Oil

Before Using

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ethiodized oil injection for lymphography in children.


Appropriate studies on the relationship of age to the effects of ethiodized oil injection have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this diagnostic test with any of the following medicines is not recommended. Your doctor may decide not to use this diagnostic test or change some of the other medicines you take.

  • Metformin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to iodinated contrast agents or
  • Asthma—May increase risk of having an allergic reaction to occur again.
  • Bleeding in the uterus or
  • Curettage or conization with 30 days or
  • Cervical erosion or
  • Endocervicitis (inflammation of the cervix) or
  • Immediate premenstrual or postmenstrual time frame or
  • Pelvic inflammatory disease
  • Pregnant—Patients with these conditions should not receive Lipiodol® for hysterosalpingography.
  • Bleeding, recent or
  • Hyperthyroidism (overactive thyroid) or
  • Trauma—Should not be used in patients with these conditions.
  • Dilated bile ducts without external drainage—Patients with this condition should not receive Lipiodol® for liver tumor imaging.
  • Heart disease or
  • Liver disease or
  • Lung disease or
  • Portal hypertension (high blood pressure in the liver portal vein) or
  • Thyroid problems—Use with caution. May make these conditions worse.
  • Advanced lung disease or
  • Advanced neoplastic disease with expected lymphatic obstruction or
  • Radiation therapy to the examined area or
  • Right-to-left cardiac shunt or
  • Surgery interrupting the lymphatic system, recent—Patients with this condition should not receive Lipiodol® for lymphography.

Proper Use

A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed within the uterus, into a lymphatic vessel, or into an artery of the liver.


Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

This medicine may cause pulmonary embolism (blood clots in the lungs). Tell your doctor right away if you have anxiety, chest pain, cough, dizziness or lightheadedness, fainting, fast heartbeat, sudden shortness of breath, or troubled breathing.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving this medicine.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  1. Abdominal or stomach pain
  2. anxiety
  3. bloated abdomen or stomach
  4. changes in vision
  5. chest pain or tightness
  6. cough
  7. decreased frequency or amount of urine
  8. depressed mood
  9. difficulty with swallowing
  10. dizziness or lightheadedness
  11. fainting
  12. fast heartbeat
  13. fever
  14. headache
  15. inflamed tissue from infection
  16. loss of appetite
  17. lower back or side pain
  18. muscle cramps and stiffness
  19. nausea or vomiting
  20. pain and fullness in the right upper abdomen or stomach
  21. pain, tenderness, or swelling of the foot or leg
  22. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  23. skin rash, hives, itching, or redness
  24. sudden shortness of breath or troubled breathing
  25. sweating
  26. swelling of the face, fingers, or lower legs
  27. trouble sleeping
  28. unusual tiredness or weakness
  29. weight gain or loss
  30. yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Delayed healing at the incision site
  2. diarrhea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.