Drug information provided by: IBM Micromedex

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

Do not take the following medicines if you are using eplerenone:

  • Amiloride (e.g., Midamor®) or
  • Clarithromycin (e.g., Biaxin®) or
  • Itraconazole (e.g., Sporanox®) or
  • Ketoconazole (e.g., Nizoral®) or
  • Nefazodone (e.g., Serzone®) or
  • Nelfinavir (e.g., Viracept®) or
  • Ritonavir (e.g., Norvir®) or
  • Spironolactone (e.g., Aldactone®) or
  • Triamterene (e.g., Dyrenium®) or
  • Troleandomycin (e.g., Tao®).

Do not take other medicines unless they have been discussed with your doctor. This especially includes potassium supplements or salt substitutes containing potassium.

This medicine may increase the amount of potassium in your blood. Check with your doctor right away if you are having abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeats; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.