Proper Use

Drug information provided by: Micromedex

It is very important that you read the information for patients and the injection instructions very carefully. Ask your healthcare professional if you have any questions.

Enfuvirtide can be given by a health care professional. However, medicines given by injection are sometimes used at home. If you will be using enfuvirtide at home, your health care professional will teach you how to get the medicine ready for injection and how the injections are to be given. Be certain that you understand exactly how to get the medicine ready for injection and how the medicine is to be injected. Do not reuse needles and syringes.

You will be shown the body areas where this shot can be given. It is usually given under the skin by injection in the upper arm, upper leg or stomach. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not give yourself a shot near your elbow, knee, groin, lower or inner buttocks, into your navel (belly button), or into any skin where you have a mole, scar, bruise, tattoos, or burn sites .

This medicine comes as a powder that must be mixed with a special liquid before using. Use only the sterile water that came with your medicine to prepare it. Do not shake the medicine after adding the water. Gently tap the vial for 10 seconds and then roll it between your hands to avoid foaming. Wait for the powdered medicine to completely dissolve in the water before using it. This may take up to 45 minutes. Before using the medicine, make sure the solution is clear, colorless, and without bubbles .

Put used needles and syringes in a puncture-resistant disposable container, or dispose of them as directed by your health care professional.

It is important to take enfuvirtide as part of a combination treatment. Be sure to take all the medicines your doctor has prescribed for you, including enfuvirtide.

Do not stop taking this medicine without checking with your doctor first.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For parenteral dosage form (injection):
    • For treatment of HIV infection:
      • Adults—90 milligrams (mg) twice a day given by injection.
      • Children—Dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Store reconstituted solution (mixed with water) in the refrigerator and use within 24 hours.