Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Black, tarry stools
  2. bleeding gums
  3. blistering, peeling, or loosening of the skin
  4. blood in the urine or stools
  5. burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  6. chest pain or tightness
  7. chills
  8. cough
  9. decrease in the amount of urine
  10. diarrhea
  11. difficulty in swallowing
  12. difficulty moving
  13. dizziness
  14. dry eyes
  15. fainting
  16. fast, slow, or irregular heartbeat
  17. fever
  18. heartburn
  19. hives, itching, skin rash
  20. hoarseness
  21. irritation
  22. joint pain, stiffness, or swelling
  23. lower back or side pain
  24. muscle pain, cramps, or stiffness
  25. noisy, rattling breathing
  26. nosebleeds
  27. pain or burning feeling in the throat
  28. painful or difficult urination
  29. pale skin
  30. pinpoint red spots on the skin
  31. red skin lesions, often with a purple center
  32. red, irritated eyes
  33. redness of the skin
  34. sensation of pins and needles
  35. severe lack or loss of strength
  36. sore throat
  37. sores, ulcers, or white spots on the lips or tongue or inside the mouth
  38. stabbing pain
  39. swelling of the eyelids, face, lips, hands, or feet
  40. trouble breathing
  41. unusual bleeding or bruising
  42. unusual tiredness or weakness
  43. vomiting
  44. weight gain

Less common

  1. Bluish color of the skin
  2. blurred vision
  3. burning or itching of the eyes
  4. changes in skin color
  5. chest discomfort
  6. confusion
  7. constipation
  8. discharge, excessive tearing
  9. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  10. lightheadedness
  11. nausea
  12. pain or discomfort in the arms, jaw, back, or neck
  13. pain, tenderness, or swelling of the foot or leg
  14. rapid, shallow breathing
  15. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  16. severe stomach pain
  17. sweating
  18. vomiting of blood or material that looks like coffee grounds


  1. Dilated neck veins
  2. extreme tiredness or weakness
  3. fast, pounding, or irregular heartbeat or pulse
  4. headache
  5. irregular breathing
  6. nervousness
  7. pounding in the ears

Incidence not known

  1. Agitation
  2. dark urine
  3. decreased awareness or responsiveness
  4. depression
  5. drowsiness
  6. dry mouth
  7. general feeling of tiredness or weakness
  8. hostility
  9. increased thirst
  10. indigestion
  11. light-colored stools
  12. loss of appetite
  13. loss of consciousness
  14. mood or mental changes
  15. muscle spasms (tetany) or twitching seizures
  16. nausea
  17. rapid, shallow breathing
  18. rectal bleeding
  19. seizures
  20. severe abdominal pain, cramping, or burning
  21. severe sleepiness
  22. stomach cramps, pain, or tenderness
  23. stomach pain, continuing
  24. tremor
  25. unusual drowsiness, dullness, or feeling of sluggishness
  26. vomiting of material that looks like coffee grounds, severe and continuing
  27. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Absent, missed, or irregular menstrual periods
  2. bad, unusual or unpleasant (after)taste
  3. change in sense of smell
  4. change in taste
  5. discoloration of the fingernails or toenails
  6. dry skin
  7. loss or thinning of the hair
  8. stopping of menstrual bleeding
  9. swelling or inflammation of the mouth
  10. weight loss

Less common

  1. Dry, red, hot, or irritated skin

Incidence not known

  1. Hearing loss
  2. pain and redness of the skin at the place of earlier radiation treatment

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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