Diclofenac And Misoprostol (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Stomach pain

Less common

1. Black, tarry stools
2. bladder pain
3. bloody or cloudy urine
4. burning feeling in the chest or stomach
5. burning while urinating
6. chest pain, discomfort, or tightness
7. chills
8. cough
9. deep or fast breathing with dizziness
10. difficult, burning, or painful urination
11. difficulty swallowing
12. dizziness
13. double vision
14. feeling of constant movement of self or surroundings
15. fever
16. frequent urge to urinate
17. heartburn
18. increased sensitivity of the skin to sunlight
19. increased volume of pale, dilute urine
20. indigestion
21. itching, skin rash
22. lightheadedness
23. longer or heavier menstrual periods
24. lower back or side pain
25. nosebleed
26. numbness of the feet, hands, and around the mouth
27. pain or burning in the throat
28. pain with swallowing
29. redness or other discoloration of the skin
30. seeing double
31. sensation of spinning
32. severe sunburn
33. sores, ulcers, or white spots on the lips or in the mouth
34. sore throat
35. stomach upset or tenderness
36. swollen glands
37. unusual bleeding or bruising
38. unusual tiredness or weakness
39. vaginal bleeding
40. vomiting with or without blood

Incidence not known

1. Ankle, knee, or great toe joint pain
2. anxiety
3. black, tarry stools
4. bleeding gums
5. blindness
6. blistering, peeling, or loosening of the skin
7. bloating or swelling of the face, arms, hands, lower legs, or feet
8. bluish color of the skin
9. blurred vision
10. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
11. burning, dry, or itching eyes
12. cloudy or dark urine
13. decreased frequency or amount of urine
14. decreased vision
15. diarrhea
16. difficulty in speaking
17. dilated neck veins
18. discharge, excessive tearing
19. dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
20. drowsiness
21. excessive muscle tone
22. eye pain
23. fainting
24. fast, irregular, pounding, or racing heartbeat or pulse
25. general feeling of illness
26. headache, severe and throbbing
27. hoarseness
28. inability to move the arms, legs, or facial muscles
29. inability to speak
30. increased sensitivity to pain or touch
31. increased thirst
32. irregular, fast or slow, or shallow breathing
33. joint pain, stiffness, or swelling
34. large, hive-like swelling on the pain, face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
35. light-colored stools
36. lightheadedness
37. loss of appetite
38. loss of consciousness
39. muscle stiffness, tension, or tightness
40. nausea
41. nervousness
42. night blindness
43. pain or discomfort in the arms, jaw, back, or neck
44. pains in the stomach, side, or abdomen, possibly radiating to the back
45. pain, warmth, or burning in the fingers, toes, and legs
46. pale or blue lips, fingernails, or skin pale skin
47. pinpoint red spots on the skin
48. pounding in the ears
49. problems with vision or hearing
50. rapid weight gain
51. red skin lesions, often with a purple center
52. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
53. redness or soreness of the skin
54. seizures
55. severe stomach cramping
56. slow heartbeat
57. slow speech
58. sneezing
59. sores, welts, or blisters
60. stiff neck or back
61. tremor
62. trouble breathing
63. unusual bleeding or bruising
64. unusual weight gain or loss
65. upper right stomach pain
66. uterine cramping and bleeding
67. vomiting of material that looks like coffee grounds, severe and continuing
68. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Belching
2. excess air or gas in the stomach or bowels
3. full feeling
4. passing gas

Less common

1. Breast pain
2. change in or loss of taste
3. confusion about identity, place, and time
4. constipation
5. continuing ringing or buzzing or other unexplained noise in the ears
6. decreased concentration
7. depression
8. difficulty in moving
9. dry mouth
10. frequent urge to defecate
11. increased clear or white vaginal discharge
12. irritability
13. itching of the vagina or genital area
14. lack or loss of strength
15. loss or thinning of hair
16. pain during sexual intercourse
17. seeing, hearing, or feeling things that are not there
18. straining while passing stool
19. thick, white vaginal discharge with no odor or with a mild odor
20. trouble sleeping

Incidence not known

1. Blemishes on the skin
2. decreased interest in sexual intercourse
3. inability to have or keep an erection
4. loss in sexual ability, desire, drive, or performance
5. pimples
6. sleepiness or unusual drowsiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: Sept. 01, 2023