Before Using

Drug information provided by: IBM Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of denosumab injection is not recommended in the pediatric population, except for teenagers with giant cell tumor of the bone. The safety and efficacy of denosumab for other conditions have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of denosumab injection in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Tofacitinib

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Blood clotting problems or
  • Cancer or
  • Dental disease, history of or
  • Dental implants, history of or
  • Dentures that do not fit well or
  • Diabetes or
  • Fractures, history of or
  • Gum disease or
  • Hypoparathyroidism (underactive parathyroid gland), history of or
  • Kidney problems, severe and may require dialysis or
  • Malabsorption syndrome (trouble absorbing food), history of or
  • Mouth surgery, history of or
  • Parathyroid surgery, history of or
  • Thyroid surgery, history of or
  • Tooth extraction, history of—May cause side effects to become worse.
  • Ear infection or
  • Eczema (skin problem) or
  • Endocarditis (heart infection) or
  • Skin infections or
  • Skin rashes or
  • Stomach infection or
  • Urinary tract infection—Use with caution. May make these conditions worse.
  • Hypocalcemia (low calcium in the blood)—Should not be given to patients with this condition.

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Portions of this document last updated: July 01, 2021

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