Side Effects

Drug information provided by: Micromedex

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Bloating or swelling of the face, arms, hands, lower legs, or feet
  2. fever
  3. rapid weight gain
  4. tingling of the hands or feet
  5. unusual weight gain or loss

Less common

  1. Abdominal or stomach pain
  2. agitation
  3. black, tarry stools
  4. bladder pain
  5. bloody or cloudy urine
  6. blurred vision
  7. chest pain or discomfort
  8. chills
  9. coma
  10. confusion
  11. convulsions
  12. cough
  13. decreased frequency or amount of urine
  14. decreased urine output
  15. depression
  16. diarrhea
  17. difficult or labored breathing
  18. difficult, burning, or painful urination
  19. dilated neck veins
  20. dizziness
  21. dry mouth
  22. extreme fatigue
  23. fainting
  24. faintness or lightheadedness when getting up suddenly from a lying or sitting position
  25. fast heartbeat
  26. frequent urge to urinate
  27. headache
  28. hostility
  29. increased blood pressure
  30. increased thirst
  31. irregular breathing
  32. irregular heartbeat
  33. irritability
  34. itching in the genital or other skin areas
  35. itching, pain, redness, swelling, tenderness, or warmth on the skin
  36. lethargy
  37. lightheadedness
  38. loss of appetite
  39. lower back or side pain
  40. mood changes
  41. muscle pain or cramps
  42. muscle twitching
  43. nausea
  44. nervousness
  45. numbness or tingling in the hands, feet, or lips
  46. pale skin
  47. pounding in the ears
  48. rapid weight gain
  49. rapid, shallow breathing
  50. scaling
  51. seizures
  52. shortness of breath
  53. slow or fast heartbeat
  54. sneezing
  55. sore throat
  56. stupor
  57. sweating
  58. swelling of the face, fingers, ankles, or hands
  59. tightness in the chest
  60. troubled breathing with exertion
  61. unusual bleeding or bruising
  62. usual tiredness or weakness
  63. vomiting of blood or material that looks like coffee grounds
  64. weight gain
  65. wheezing


  1. Bleeding gums
  2. blood in the urine or stools
  3. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  4. clay-colored stools
  5. dark urine
  6. difficulty with moving
  7. drowsiness
  8. eye pain
  9. feeling of warmth
  10. feeling unusually cold
  11. general feeling of illness
  12. headache
  13. hives
  14. hoarseness
  15. increase in bone pain
  16. irritation
  17. itching
  18. joint pain, stiffness, or swelling
  19. loss of appetite
  20. mood or mental changes
  21. muscle aching or cramping
  22. muscle spasms (tetany) or twitching
  23. no blood pressure or pulse
  24. pain in the joints
  25. pinpoint red spots on the skin
  26. rapid or irregular heartbeat
  27. rash
  28. redness of the face, neck, arms, and occasionally, upper chest
  29. redness of the skin
  30. redness, blistering, peeling, or loosening of the skin
  31. shivering
  32. skin rash, encrusted, scaly and oozing
  33. sore throat
  34. sores, ulcers, or white spots on the lips or in the mouth
  35. stopping of heart
  36. swelling of the eyelids, face, lips, hands, or feet
  37. swollen glands
  38. swollen joints
  39. swollen, painful, or tender lymph glands in the neck, armpit, or groin
  40. trembling
  41. troubled breathing or swallowing
  42. twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  43. unconsciousness
  44. unpleasant breath odor
  45. unusual bleeding or bruising
  46. vomiting of blood
  47. yellow eyes or skin

Incidence not known

  1. Abdominal or stomach cramps
  2. abdominal or stomach tenderness
  3. diarrhea, watery and severe, which may also be bloody
  4. difficulty with swallowing
  5. dry cough
  6. pain
  7. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  8. unusual weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  2. diarrhea, mild
  3. difficulty having a bowel movement (stool)

Less common

  1. Anxiety
  2. back pain
  3. blurred vision
  4. cold sweats
  5. coma
  6. cool, pale skin
  7. decreased appetite
  8. depression
  9. flushed, dry skin
  10. fruit-like breath odor
  11. increased hunger
  12. increased urination
  13. itching of the vagina or outside genitals
  14. lack or loss of strength
  15. limb pain
  16. nervousness
  17. nightmares
  18. pain during sexual intercourse
  19. shakiness
  20. skin rash
  21. sleeplessness
  22. slurred speech
  23. sweating
  24. thick, white, curd-like vaginal discharge without odor or with mild odor
  25. trouble sleeping
  26. unable to sleep
  27. unexplained weight loss


  1. Acid or sour stomach
  2. bad, unusual, or unpleasant (after) taste
  3. belching
  4. change in taste
  5. continuing ringing or buzzing or other unexplained noise in the ears
  6. excess air or gas in the stomach or intestines
  7. feeling of constant movement of self or surroundings
  8. full feeling
  9. hearing loss
  10. heartburn
  11. indigestion
  12. pain or discomfort in the chest, upper stomach, or throat
  13. passing gas
  14. pressure in the stomach
  15. red, sore eyes
  16. seeing, hearing, or feeling things that are not there
  17. sensation of spinning
  18. sore mouth or tongue
  19. swelling of the abdominal or stomach area
  20. swelling or inflammation of the mouth
  21. weakness
  22. white patches in the mouth or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.