Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Changes in skin color
  2. pain
  3. swelling of the foot or leg
  4. tenderness

Rare

  1. Agitation
  2. coma
  3. confusion
  4. decreased urine output
  5. depression
  6. dizziness
  7. headache
  8. hostility
  9. irritability
  10. lethargy
  11. muscle twitching
  12. nausea
  13. rapid weight gain
  14. seizures
  15. stupor
  16. swelling of the face, ankles, or hands
  17. unusual tiredness or weakness

Incidence not known

  1. Abdominal or stomach cramps or tenderness
  2. back, leg, or stomach pains
  3. bleeding and bruising
  4. bleeding gums
  5. blistering, peeling, or loosening of the skin
  6. bloating
  7. bloody or cloudy urine
  8. bloody, black, or tarry stools
  9. chest pain
  10. chills
  11. clay-colored stools
  12. cloudy urine
  13. cough
  14. coughing up blood
  15. cracks in the skin
  16. dark urine
  17. decrease in urine output or decrease in urine-concentrating ability
  18. diarrhea
  19. diarrhea, watery and severe, which may also be bloody
  20. difficult or labored breathing
  21. difficult or painful urination
  22. difficulty with breathing, chewing, swallowing, or talking
  23. dizziness
  24. double vision
  25. drooping eyelids
  26. fast heartbeat
  27. feeling of discomfort
  28. fever
  29. general body swelling
  30. greatly decreased frequency of urination or amount of urine
  31. headache
  32. high fever
  33. hives
  34. increased menstrual flow or vaginal bleeding
  35. increased thirst
  36. inflammation of the joints
  37. itching
  38. itching of the vagina or genital area
  39. joint or muscle pain
  40. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  41. loss of appetite
  42. loss of heat from the body
  43. muscle aches
  44. muscle weakness
  45. nosebleeds
  46. pain during sexual intercourse
  47. pale skin
  48. paralysis
  49. prolonged bleeding from cuts
  50. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  51. rash
  52. red or black, tarry stools
  53. red or dark brown urine
  54. red skin lesions, often with a purple center
  55. red, irritated eyes
  56. red, swollen skin
  57. scaly skin
  58. severe tiredness
  59. shortness of breath
  60. sore throat
  61. sores, ulcers, or white spots on the lips or in the mouth
  62. sudden decrease in the amount of urine
  63. swelling of the feet or lower legs
  64. swollen lymph glands
  65. swollen or painful glands
  66. thick, white vaginal discharge with no odor or with a mild odor
  67. tightness in the chest
  68. troubled breathing with exertion
  69. unexplained bleeding or bruising
  70. unpleasant breath odor
  71. unusual bleeding or bruising
  72. unusual weight loss
  73. vomiting
  74. vomiting of blood
  75. wheezing
  76. yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Red streaks on the skin
  2. swelling, tenderness, or pain at the injection site

Incidence not known

  1. Hives or welts
  2. redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: Feb. 01, 2023