Cefoperazone (intramuscular route, intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of cefoperazone injection in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cefoperazone injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving cefoperazone injection.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Cholera Vaccine, Live
• Heparin

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse, history of or
• Malabsorption problems (eg, cystic fibrosis) or
• Poor nutrition status—May increase risk of having vitamin K deficiency.

• Allergy to beta-lactam antibiotics, history of—Should not be used in patients with this condition.

• Bleeding problems or
• Kidney disease or
• Stomach or bowel disease (eg, colitis), history of—Use with caution. May make these conditions worse.

• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Rare

• Black, tarry, stools
• bluish color of the skin
• chills
• cough
• dark urine
• difficulty in breathing or swallowing
• fast heartbeat
• fever
• general tiredness and weakness
• light-colored stools
• lower back or side pain
• nausea
• pain or swelling at the injection site
• painful or difficult urination
• pale skin
• skin itching, rash, or redness
• sore throat
• stomach cramps
• swelling of the face, throat, or tongue
• swelling of the foot or leg
• tenderness
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness
• upper right stomach pain
• vomiting
• watery or bloody diarrhea
• yellow eyes and skin

Incidence not known

• Bleeding gums
• bleeding under the skin
• blistering, peeling, loosening of the skin
• blood in the urine or stools
• clay-colored stools
• cold, clammy skin
• confusion
• coughing up blood
• dizziness
• fast, weak pulse
• headache
• increased menstrual flow or vaginal bleeding
• joint or muscle pain
• lightheadedness
• loss of appetite
• nosebleeds
• paralysis
• pinpoint red spots on the skin
• prolonged bleeding from cuts
• red, irritated eyes
• red or black, tarry stools
• red or dark brown urine
• red skin lesions, often with a purple center
• stomach pain
• sweating
• unpleasant breath odor
• vomiting of blood