Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Diarrhea
  2. loss of fingerprints
  3. nausea
  4. numbness, pain, tingling, or other unusual sensations in the palms of the hands or bottoms of the feet
  5. pain, blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
  6. pain, redness, swelling, sores, or ulcers in your mouth or on your lips
  7. stomach pain
  8. unusual tiredness or weakness
  9. vomiting

Less common or rare

  1. Agitation
  2. back pain
  3. bleeding and bruising
  4. bleeding gums
  5. blood in the urine or stools
  6. bloody nose
  7. bloody or black, tarry stools
  8. blurred vision
  9. burning, dry, or itching eyes
  10. chest pain or tightness
  11. chills
  12. clumsiness or unsteadiness
  13. cold
  14. collapse
  15. coma
  16. confusion
  17. constipation
  18. cough or hoarseness (accompanied by fever or chills)
  19. cough producing mucus
  20. coughing or spitting up blood
  21. dark urine
  22. decreased frequency or amount of urine
  23. difficulty with breathing
  24. difficulty with swallowing or pain in the back of throat or chest when swallowing
  25. discharge from the eyes
  26. drowsiness
  27. dry mouth
  28. excessive tearing
  29. extra heartbeats
  30. eye redness, irritation, or pain
  31. fainting
  32. fast or irregular heartbeat
  33. fever or chills
  34. flu-like symptoms
  35. hallucinations
  36. headache, sudden and severe
  37. heavier menstrual periods
  38. high fever
  39. hot, red skin on the feet or legs
  40. inability to speak
  41. increased menstrual flow or vaginal bleeding
  42. increased thirst
  43. irritability
  44. itching in the genital or other skin areas
  45. lightheadedness
  46. light-colored stools
  47. loss of consciousness
  48. lower back or side pain (accompanied by fever or chills)
  49. muscle aches, cramps, or spasms
  50. nosebleeds
  51. numbness or tingling in the hands, feet, or lips
  52. painful or difficult urination (accompanied by fever or chills)
  53. painful, swollen feet or legs
  54. pain, tenderness, or swelling in the upper abdominal or stomach area
  55. pale skin
  56. paralysis
  57. pinpoint red spots on the skin
  58. problems with coordination
  59. prolonged bleeding from cuts
  60. rapid, shallow breathing
  61. red or dark brown urine
  62. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  63. scaling
  64. seizures
  65. severe constipation
  66. skin rash or itching
  67. slow or irregular heartbeat
  68. slurred speech
  69. sneezing
  70. sores, ulcers, or white spots on the lips or in the mouth
  71. sore throat
  72. stiff neck
  73. stomach bloating, burning, or cramping
  74. stuffy nose
  75. swelling of the face, fingers, feet, or lower legs
  76. swelling of the lymph nodes
  77. swollen glands
  78. temporary blindness
  79. trouble with speaking
  80. trouble breathing
  81. unexplained nosebleeds
  82. unusual bleeding or bruising
  83. unusual lump or swelling in the chest
  84. unusual tiredness or weakness
  85. vomiting blood or material that looks like coffee grounds
  86. weakness in the arm or leg on one side of the body, sudden and severe
  87. weight gain or loss
  88. white patches in the mouth or throat or on the tongue
  89. white patches with diaper rash
  90. yellow eyes or skin

Incidence not known

  1. Blistering, peeling, or loosening of the skin
  2. chest discomfort or heaviness
  3. dilated neck veins
  4. dizziness
  5. eye irritation or pain
  6. irregular breathing
  7. joint or muscle pain
  8. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  9. no blood pressure or pulse
  10. pain or discomfort in the arms, jaw, back, or neck
  11. red irritated eyes
  12. red skin lesion, often with a purple center
  13. stopping of heart
  14. sweating
  15. unconsciousness
  16. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  2. changes or discoloration in the fingernails or toenails
  3. difficulty with moving
  4. discouragement
  5. headache
  6. heartburn
  7. increased sensitivity of the skin to sunlight
  8. muscle pain
  9. pain
  10. pain and redness of the skin at the place of x-ray treatment
  11. pain in the joints or limbs
  12. red, sore eyes
  13. sunken eyes
  14. thirst
  15. trouble sleeping
  16. weakness
  17. wrinkled skin

Rare

  1. Bone pain
  2. change in color of treated skin
  3. difficulty with walking
  4. discouragement
  5. feeling of constant movement of self or surroundings
  6. feeling sad or empty
  7. full or bloated feeling or pressure in the stomach
  8. general feeling of discomfort or illness
  9. hot flushes
  10. impaired balance
  11. increased sweating
  12. joint pain
  13. lack of appetite
  14. loss of interest or pleasure
  15. muscle weakness
  16. noisy breathing
  17. pain in the rectum
  18. pain, swelling, or redness in the joints
  19. passing less gas
  20. rough, scratchy sound to voice
  21. runny nose
  22. sensation of spinning
  23. shakiness in the legs, arms, hands, or feet
  24. shivering
  25. sores on the skin
  26. swelling of the stomach area
  27. tremor or shaking of the hands or feet
  28. trouble concentrating
  29. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Portions of this document last updated: March 01, 2023

Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.