Side Effects

Drug information provided by: IBM Micromedex

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Abdominal or stomach pain
  2. diarrhea
  3. loss of fingerprints
  4. nausea
  5. numbness, pain, tingling, or other unusual sensations in the palms of the hands or bottoms of the feet
  6. pain, blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
  7. pain, redness, swelling, sores, or ulcers in your mouth or on your lips
  8. unusual tiredness or weakness
  9. vomiting

Less common or rare

  1. Abdominal or stomach cramping or pain (severe)
  2. agitation
  3. back pain
  4. bleeding and bruising
  5. bleeding gums
  6. blood in the urine or stools
  7. bloody nose
  8. bloody or black, tarry stools
  9. blurred vision
  10. burning, dry, or itching eyes
  11. chest pain
  12. chills
  13. clumsiness or unsteadiness
  14. cold
  15. collapse
  16. coma
  17. confusion
  18. constipation
  19. convulsions
  20. cough or hoarseness (accompanied by fever or chills)
  21. cough producing mucus
  22. coughing or spitting up blood
  23. dark urine
  24. decreased frequency or amount of urine
  25. difficulty with breathing
  26. difficulty with swallowing or pain in the back of throat or chest when swallowing
  27. discharge from the eyes
  28. drowsiness
  29. dry mouth
  30. excessive tearing
  31. extra heartbeats
  32. eye redness, irritation, or pain
  33. fainting
  34. fast or irregular heartbeat
  35. fever or chills
  36. flu-like symptoms
  37. hallucinations
  38. headache, sudden and severe
  39. heavier menstrual periods
  40. high fever
  41. hot, red skin on the feet or legs
  42. inability to speak
  43. increased menstrual flow or vaginal bleeding
  44. increased thirst
  45. irritability
  46. itching in the genital or other skin areas
  47. lightheadedness
  48. light-colored stools
  49. loss of consciousness
  50. lower back or side pain (accompanied by fever or chills)
  51. muscle aches or cramps
  52. muscle spasms
  53. nosebleeds
  54. numbness or tingling in the hands, feet, or lips
  55. painful or difficult urination (accompanied by fever or chills)
  56. painful, swollen feet or legs
  57. pain, tenderness, or swelling in the upper abdominal or stomach area
  58. pale skin
  59. paralysis
  60. pinpoint red spots on the skin
  61. problems with coordination
  62. prolonged bleeding from cuts
  63. rapid, shallow breathing
  64. red or dark brown urine
  65. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  66. scaling
  67. seizures
  68. severe constipation
  69. skin rash or itching
  70. slow or irregular heartbeat
  71. slurred speech
  72. sneezing, sore throat, or stuffy nose
  73. sores, ulcers, or white spots on the lips or in the mouth
  74. stiff neck
  75. stomach bloating, burning, or cramping
  76. swelling of the face, fingers, feet, or lower legs
  77. swelling of the lymph nodes
  78. swollen glands
  79. temporary blindness
  80. tiredness or weakness
  81. trouble with speaking
  82. troubled breathing or tightness in the chest
  83. unexplained nosebleeds
  84. unusual bleeding or bruising
  85. unusual lump or swelling in the chest
  86. vomiting blood or material that looks like coffee grounds
  87. weakness in the arm or leg on one side of the body, sudden and severe
  88. weight gain or loss
  89. white patches in the mouth or throat or on the tongue
  90. white patches with diaper rash
  91. yellow eyes or skin

Incidence not known

  1. Chest discomfort, tightness, or heaviness
  2. dilated neck veins
  3. dizziness
  4. extreme fatigue
  5. irregular breathing
  6. no blood pressure or pulse
  7. pain or discomfort in the arms, jaw, back, or neck
  8. stopping of heart
  9. sweating
  10. unconsciousness
  11. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  2. changes or discoloration in the fingernails or toenails
  3. difficulty with moving
  4. discouragement
  5. headache
  6. heartburn
  7. increased sensitivity of the skin to sunlight
  8. muscle pain
  9. pain
  10. pain and redness of the skin at the place of x-ray treatment
  11. pain in the joints or limbs
  12. red, sore eyes
  13. sunken eyes
  14. thirst
  15. trouble sleeping
  16. weakness
  17. wrinkled skin


  1. Bone pain
  2. change in color of treated skin
  3. difficulty with walking
  4. discouragement
  5. feeling of constant movement of self or surroundings
  6. feeling sad or empty
  7. full or bloated feeling or pressure in the stomach
  8. general feeling of discomfort or illness
  9. hot flushes
  10. impaired balance
  11. increased sweating
  12. joint pain
  13. lack of appetite
  14. loss of interest or pleasure
  15. muscle weakness
  16. noisy breathing
  17. pain in the rectum
  18. pain, swelling, or redness in the joints
  19. passing less gas
  20. rough, scratchy sound to voice
  21. runny nose
  22. sensation of spinning
  23. shakiness in the legs, arms, hands, or feet
  24. shivering
  25. sores on the skin
  26. swelling of abdominal or stomach area
  27. tremor or shaking of the hands or feet
  28. trouble concentrating
  29. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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