Butalbital, Aspirin, And Codeine (Oral Route) Before Using

Description and Brand Names

Drug information provided by: Merative, Micromedex®

Descriptions

Butalbital, aspirin, and codeine combinations are used to relieve headaches and other kinds of pain. These combination medicines may provide better pain relief than either aspirin or codeine used alone. In some cases, relief of pain may come at lower doses of each medicine.

Codeine is a narcotic analgesic that acts in the central nervous system (CNS) to relieve pain. Many of its side effects are also caused by actions in the CNS. Butalbital belongs to the group of medicines called barbiturates. Barbiturates also act in the CNS to produce their effects.

When you use butalbital or codeine for a long time, your body may get used to the medicine so that larger amounts are needed to produce the same effects. This is called tolerance to the medicine. Also, butalbital and codeine may become habit-forming (causing mental or physical dependence) when they are used for a long time or in large doses. Physical dependence may lead to withdrawal symptoms when you stop taking the medicine. In patients who get headaches, the first symptom of withdrawal may be new (rebound) headaches.

This combination also contains caffeine. Caffeine may help to relieve headaches. However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it.

Aspirin is not a narcotic and does not cause physical dependence. However, it may cause other unwanted effects if too much is taken.

This combination medicine is available only with your doctor's prescription

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

For butalbital: Although butalbital often causes drowsiness, some children become excited after taking it.

For aspirin: Do not give a medicine containing aspirin to a child with fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor. This is very important because aspirin may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Children who do not have a virus infection may also be more sensitive to the effects of aspirin, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. This may increase the chance of side effects during treatment.

For caffeine: There is no specific information comparing use of caffeine in children up to 12 years of age with use in other age groups. However, caffeine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

For butalbital: Confusion, depression, or excitement may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of butalbital.

For aspirin: Elderly patients are more sensitive than younger adults to the effects of aspirin. This may increase the chance of side effects during treatment.

For codeine: Breathing problems may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of codeine.

For caffeine: Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of caffeine in the elderly with use in other age groups.

Breastfeeding

Butalbital

Aspirin

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Codeine

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Abrocitinib
Defibrotide
Dichlorphenamide
Furazolidone
Influenza Virus Vaccine, Live
Iproniazid
Isocarboxazid
Ketorolac
Linezolid
Methylene Blue
Moclobemide
Nalmefene
Naltrexone
Nialamide
Ozanimod
Phenelzine
Procarbazine
Rasagiline
Safinamide
Samidorphan
Selegiline
Toloxatone
Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Abiraterone Acetate
Acarbose
Aceclofenac
Acemetacin
Acenocoumarol
Acepromazine
Acetazolamide
Aclidinium
Alclometasone
Aldosterone
Alfentanil
Alipogene Tiparvovec
Almotriptan
Alosetron
Alprazolam
Alteplase, Recombinant
Amantadine
Amcinonide
Amifampridine
Amikacin
Amiloride
Amineptine
Amiodarone
Amitriptyline
Amitriptylinoxide
Amobarbital
Amoxapine
Amphetamine
Amphotericin B
Amprenavir
Amtolmetin Guacil
Anagrelide
Anileridine
Anisindione
Apalutamide
Apixaban
Aprepitant
Aprobarbital
Ardeparin
Argatroban
Aripiprazole
Aripiprazole Lauroxil
Armodafinil
Asenapine
Atazanavir
Atropine
Bacitracin
Baclofen
Barbital
Beclomethasone
Belladonna
Bemetizide
Bemiparin
Benazepril
Bendroflumethiazide
Benperidol
Bentazepam
Benzhydrocodone
Benzphetamine
Benzthiazide
Benztropine
Betamethasone
Betrixaban
Biperiden
Bivalirudin
Boceprevir
Bosentan
Brinzolamide
Bromazepam
Bromfenac
Bromopride
Brompheniramine
Budesonide
Bufexamac
Bumetanide
Buprenorphine
Bupropion
Buspirone
Butabarbital
Butorphanol
Calcium Oxybate
Cannabidiol
Cannabis
Canrenoate
Canrenone
Caplacizumab-yhdp
Capreomycin
Captopril
Carbamazepine
Carbinoxamine
Carisoprodol
Carphenazine
Celecoxib
Cenobamate
Certoparin
Cetirizine
Chloral Hydrate
Chlordiazepoxide
Chlorothiazide
Chlorpheniramine
Chlorpromazine
Chlorpropamide
Chlorthalidone
Chlorzoxazone
Choline Salicylate
Ciclesonide
Cilostazol
Cimetidine
Cinacalcet
Ciprofloxacin
Cisplatin
Citalopram
Clarithromycin
Clemastine
Clidinium
Clobazam
Clobetasol
Clobetasone
Clocortolone
Clomipramine
Clonazepam
Clonixin
Clopamide
Clopidogrel
Clorazepate
Cloxazolam
Clozapine
Cobicistat
Cocaine
Conivaptan
Cortisone
Crizotinib
Curcumin
Cyclobenzaprine
Cyclopenthiazide
Cyclopentolate
Cyclosporine
Cyclothiazide
Cyproheptadine
Dabigatran Etexilate
Dalteparin
Danaparoid
Dantrolene
Daridorexant
Darifenacin
Darunavir
Deflazacort
Delavirdine
Delorazepam
Desipramine
Desirudin
Desmopressin
Desonide
Desoximetasone
Desvenlafaxine
Dexamethasone
Dexibuprofen
Dexketoprofen
Dexmedetomidine
Dextroamphetamine
Dextromethorphan
Dezocine
Diacetylmorphine
Diazepam
Diazoxide
Dibenzepin
Dichloralphenazone
Diclofenac
Dicumarol
Dicyclomine
Difenoxin
Diflorasone
Diflucortolone
Diflunisal
Difluprednate
Digoxin
Dihydrocodeine
Diltiazem
Dimenhydrinate
Diphenhydramine
Diphenoxylate
Dipyrone
Dolasetron
Donepezil
Dorzolamide
Dothiepin
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Doxylamine
Dronedarone
Droperidol
Drospirenone
Droxicam
Duloxetine
Edoxaban
Efavirenz
Elagolix
Eletriptan
Emtricitabine
Enalapril
Enalaprilat
Enflurane
Enoxaparin
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Eplerenone
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Erythromycin
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Esketamine
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Estazolam
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Eterobarb
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Ethchlorvynol
Ethinyl Estradiol
Ethopropazine
Ethylmorphine
Etodolac
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Etonogestrel
Etoricoxib
Etozolin
Etravirine
Fedratinib
Felbinac
Fenfluramine
Fenoprofen
Fentanyl
Fepradinol
Feprazone
Fesoterodine
Feverfew
Fexinidazole
Flavoxate
Flibanserin
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Flucloronide
Fluconazole
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Flufenamic Acid
Flumethasone
Flunisolide
Flunitrazepam
Fluocinolone
Fluocinonide
Fluocortin
Fluocortolone
Fluorometholone
Fluoxetine
Fluphenazine
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Flurazepam
Flurbiprofen
Fluspirilene
Fluticasone
Fluvoxamine
Fondaparinux
Fosamprenavir
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Fosinopril
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Ginkgo
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Gossypol
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Ibrutinib
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Imatinib
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Indapamide
Indinavir
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Inotersen
Ipratropium
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Isoflurane
Itraconazole
Ivacaftor
Kanamycin
Ketamine
Ketazolam
Ketobemidone
Ketoconazole
Ketoprofen
Lacosamide
Larotrectinib
Lasmiditan
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Lenacapavir
Lepirudin
Letermovir
Levocetirizine
Levomilnacipran
Levorphanol
Linezolid
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Lisinopril
Lithium
Lofepramine
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Lomitapide
Lopinavir
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Lorcaserin
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Macimorelin
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Metaclazepam
Metaxalone
Metformin
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Methamphetamine
Methazolamide
Methdilazine
Methocarbamol
Methohexital
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Methotrimeprazine
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Methylene Blue
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Metolazone
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Mirabegron
Mirtazapine
Mitotane
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Moexipril
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Moricizine
Morniflumate
Morphine
Morphine Sulfate Liposome
Nabumetone
Nadroparin
Nafcillin
Nalbuphine
Naproxen
Naratriptan
Nateglinide
Nefazodone
Nelfinavir
Neomycin
Nepafenac
Netilmicin
Netupitant
Nevirapine
Nicomorphine
Nicorandil
Nifedipine
Niflumic Acid
Nilotinib
Nimesulide
Nimesulide Beta Cyclodextrin
Nitrazepam
Nitrous Oxide
Nordazepam
Norethindrone
Norgestimate
Norgestrel
Nortriptyline
Olanzapine
Oliceridine
Omaveloxolone
Ondansetron
Opipramol
Opium
Opium Alkaloids
Orphenadrine
Oxaprozin
Oxazepam
Oxcarbazepine
Oxitropium Bromide
Oxybutynin
Oxycodone
Oxymorphone
Oxyphenbutazone
Ozanimod
Palbociclib
Palonosetron
Papaveretum
Paramethasone
Parecoxib
Paregoric
Parnaparin
Paromomycin
Paroxetine
Pemetrexed
Pentazocine
Pentobarbital
Pentosan Polysulfate Sodium
Pentoxifylline
Perampanel
Perazine
Periciazine
Perindopril
Perphenazine
Phenelzine
Phenindione
Phenobarbital
Phenprocoumon
Phenylbutazone
Phenytoin
Piketoprofen
Pinazepam
Pipenzolate Bromide
Piperacetazine
Piperaquine
Pipotiazine
Piracetam
Pirenzepine
Piretanide
Piritramide
Piroxicam
Plazomicin
Polythiazide
Posaconazole
Potassium Citrate
Potassium Oxybate
Pranoprofen
Prasugrel
Prazepam
Prednicarbate
Prednisolone
Prednisone
Pregabalin
Primidone
Procarbazine
Prochlorperazine
Procyclidine
Proglumetacin
Promazine
Promethazine
Propantheline
Propiverine
Propofol
Propyphenazone
Proquazone
Protein C
Protriptyline
Quazepam
Quetiapine
Quinapril
Quinethazone
Quinidine
Quinine
Ramelteon
Ramipril
Ranitidine
Ranolazine
Rasagiline
Remifentanil
Remimazolam
Remoxipride
Repaglinide
Reteplase, Recombinant
Reviparin
Rifabutin
Rifampin
Rifapentine
Rimexolone
Ritonavir
Rivaroxaban
Rizatriptan
Rofecoxib
Rolapitant
Ropeginterferon Alfa-2b-njft
Safinamide
Salicylic Acid
Salsalate
Saquinavir
Scopolamine
Secobarbital
Selegiline
Selumetinib
Sertindole
Sertraline
Sibutramine
Sodium Oxybate
Sodium Salicylate
Solifenacin
Spectinomycin
Spirapril
Spironolactone
St John's Wort
Stramonium
Streptomycin
Sufentanil
Sulindac
Sulodexide
Sulpiride
Sumatriptan
Suvorexant
Tacrolimus
Tapentadol
Telaprevir
Telithromycin
Temazepam
Tenofovir Alafenamide
Tenofovir Disoproxil Fumarate
Tenoxicam
Terbinafine
Terodiline
Tetrazepam
Thiethylperazine
Thiopental
Thiopropazate
Thioridazine
Thiothixene
Tianeptine
Tiaprofenic Acid
Ticagrelor
Ticlopidine
Tilidine
Tinzaparin
Tiotropium
Tirofiban
Tizanidine
Tobramycin
Tolazamide
Tolbutamide
Tolfenamic Acid
Tolmetin
Tolonium Chloride
Tolterodine
Topiramate
Torsemide
Tramadol
Trandolapril
Tranylcypromine
Trazodone
Treprostinil
Triamcinolone
Triamterene
Triazolam
Trichlormethiazide
Trifluoperazine
Trifluperidol
Triflupromazine
Trihexyphenidyl
Trimeprazine
Trimipramine
Tropicamide
Trospium
Tryptophan
Turmeric
Ulipristal
Umeclidinium
Valdecoxib
Valproic Acid
Vancomycin
Varicella Virus Vaccine, Live
Venlafaxine
Verapamil
Vilazodone
Voriconazole
Vortioxetine
Voxelotor
Warfarin
Xipamide
Zaleplon
Ziprasidone
Zolmitriptan
Zolpidem
Zopiclone
Zotepine
Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol
Atenolol
Betaxolol
Bisoprolol
Carteolol
Carvedilol
Celiprolol
Delapril
Esmolol
Imidapril
Labetalol
Levobunolol
Metipranolol
Metoprolol
Nadolol
Nebivolol
Nitroglycerin
Ospemifene
Oxprenolol
Penbutolol
Pindolol
Prednisone
Probenecid
Propranolol
Sotalol
St John's Wort
Streptokinase
Tamarind
Temocapril
Tenecteplase
Timolol
Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Proper Use

Take this medicine with food or a full glass (8 ounces) of water to lessen stomach irritation.

Do not take this medicine if it has a strong vinegar-like odor. This odor means the aspirin in it is breaking down. If you have any questions about this, check with your health care professional.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If butalbital or codeine is taken regularly (for example, every day), it may become habit-forming (causing mental or physical dependence). Regular use of caffeine can also cause physical dependence. Dependence is especially likely to occur in people who take these medicines to relieve frequent headaches. Also, taking too much of this combination medicine may cause stomach problems or other medical problems.

This medicine will relieve a headache best if you take it as soon as the headache begins. If you get warning signs of a migraine, take this medicine as soon as you are sure that the migraine is coming. This may even stop the headache pain from occurring. Lying down in a quiet, dark room for a while after taking the medicine also helps to relieve headaches.

People who get a lot of headaches may need to take a different medicine to help prevent headaches. It is important that you follow your doctor's directions about taking the other medicine, even if your headaches continue to occur. Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headaches should occur less often, and they should be less severe and easier to relieve than before. This will reduce the amount of headache relievers that you need. If you do not notice any improvement after several weeks of headache-preventing treatment, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules and tablets):
- For relieving pain:
  - Adults—One or 2 capsules or tablets every four hours as needed. You should not take more than six capsules or tablets a day.
  - Children—Dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm .

Precautions

Check with your doctor:

If the medicine stops working as well as it did when you first started using it. This may mean that you are in danger of becoming dependent on the medicine. Do not try to get better pain relief by increasing the dose
If you are having headaches more often than you did before you started using this medicine. This is especially important if a new headache occurs within 1 day after you took your last dose of headache medicine, headaches begin to occur every day, or a headache continues for several days in a row. This may mean that you are dependent on the headache medicine. Continuing to take this medicine will cause even more headaches later on. Your doctor can give you advice on how to relieve the headaches.

Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take. If any contain a narcotic, a barbiturate, aspirin, or other salicylates, including diflunisal, check with your doctor or pharmacist. Taking them together with this medicine may cause an overdose.

Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". Contact your doctor immediately if you experience extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine". As a result, there is too much morphine in the body and more side effects of morphine than usual

If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to a morphine overdose in the nursing baby and cause very serious side effects . For nursing mothers taking this medicine:

Talk to your doctor if you have any questions about taking codeine or about how this medicine may affect your baby.
Call your doctor if you become extremely tired and have difficulty caring for your baby.
Your baby should generally nurse every two to three hours and should not sleep more than four hours at a time.
Check with your doctor or hospital emergency room immediately if your baby shows signs of increased sleepiness (more than usual), difficulty breast-feeding, difficulty breathing, or limpness. These may be symptoms of an overdose and need immediate medical attention .

The butalbital and the codeine in this medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; other barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Also, stomach problems may be more likely to occur if you drink alcoholic beverages while you are taking aspirin. Therefore, do not drink alcoholic beverages, and check with your doctor before taking any of the medicines listed above, while you are using this medicine.

This medicine may cause some people to become drowsy, dizzy, or lightheaded, or to feel a false sense of well-being. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded.

Dizziness, light-headedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Lying down for a while may relieve these effects.

Nausea or vomiting may occur, especially after the first couple of doses. This effect may go away if you lie down for a while. However, if nausea or vomiting continues, check with your doctor.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine. Serious side effects can occur if your medical doctor or dentist gives you certain medicines without knowing that you have taken butalbital or codeine.

Do not take this medicine for 5 days before any planned surgery, including dental surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.

Before you have any medical tests, tell the person in charge that you are taking this medicine. The caffeine in this combination interferes with the results of certain tests that use dipyridamole (e.g., Persantine) to help show how well blood is flowing to your heart. Caffeine should not be taken for 8 to 12 hours before the test. The results of some other tests may also be affected by this medicine.

If you have been taking large amounts of this medicine, or if you have been taking it regularly for several weeks or more, do not suddenly stop using it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely, to lessen the chance of withdrawal side effects.

If you think you or anyone else may have taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine or taking alcohol or CNS depressants with this medicine may lead to unconsciousness or death. Signs of overdose of this medicine include convulsions (seizures); hearing loss; confusion; ringing or buzzing in the ears; severe excitement, nervousness, or restlessness; severe dizziness; severe drowsiness; unusually slow or troubled breathing; and severe weakness.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

The following side effects may mean that a serious allergic reaction is occurring. Check with your doctor or get emergency help immediately if they occur, especially if several of them occur at the same time.

Less common or rare

Bluish discoloration or flushing or redness of skin (occurring together with other effects listed in this section)
coughing, shortness of breath, troubled breathing, tightness in chest, or wheezing
difficulty in swallowing
dizziness or feeling faint (severe)
hive-like swellings (large) on eyelids, face, lips, or tongue
skin rash, itching, or hives
stuffy nose (occurring together with other effects listed in this section)

Also check with your doctor immediately if any of the following side effects occur, especially if several of them occur together:

Rare

Bleeding or crusting sores on lips
chest pain
fever with or without chills
red, thickened, or scaly skin
sores, ulcers, or white spots in mouth (painful)
sore throat (unexplained)
tenderness, burning, or peeling of skin

Symptoms of overdose

Anxiety, confusion, excitement, irritability, nervousness, restlessness, or trouble in sleeping (severe, especially with products containing caffeine)
cold, clammy skin
convulsions (seizures)
diarrhea (severe or continuing)
dizziness, light-headedness, drowsiness, or weakness (severe)
frequent urination (for products containing caffeine)
hallucinations (seeing, hearing, or feeling things that are not there)
increased sensitivity to touch or pain (for products containing caffeine)
increased thirst
low blood pressure
muscle trembling or twitching (for products containing caffeine)
nausea or vomiting (severe or continuing), sometimes with blood
pinpoint pupils of eyes
ringing or buzzing in ears (continuing) or hearing loss
seeing flashes of "zig-zag'' lights (for products containing caffeine)
slow, fast, or irregular heartbeat
slow, fast, irregular, or troubled breathing
slurred speech
staggering
stomach pain (severe)
uncontrollable flapping movements of the hands (especially in elderly patients)
unusual movements of the eyes
vision problems
Difficulty breathing
difficulty nursing
increased sleepiness (more than usual)
limpness

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Bloody or black, tarry stools
bloody urine
confusion or mental depression
pinpoint red spots on skin
skin rash, hives, or itching (without other signs of an allergic reaction to aspirin listed above)
sore throat and fever
stomach pain (severe)
swollen or painful glands
trembling or uncontrolled muscle movements
unusual bleeding or bruising
unusual excitement (mild)
unusual tiredness or weakness (mild)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bloated or "gassy" feeling
dizziness, light-headedness, or drowsiness (mild)
heartburn or indigestion
nausea, vomiting, or stomach pain (occurring without other symptoms of overdose)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/butalbital-aspirin-and-codeine-oral-route/before-using/drg-20069307

Butalbital, Aspirin, And Codeine (Oral Route)

Description and Brand Names

Descriptions

Before Using

Allergies

Pediatric

Geriatric

Breastfeeding

Drug Interactions

Other Interactions

Other Medical Problems

Proper Use

Dosing

Missed Dose

Storage

Precautions

Side Effects

Less common or rare

Rare

Symptoms of overdose

Less common or rare

More common

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