Proper Use

Drug information provided by: Micromedex

To make using becaplermin as safe and reliable as possible, you should understand how and when to use this medicine and what effects may be expected.

This medicine comes with a Medication Guide and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Use this medicine only on your skin and only on the area prescribed by your doctor. Do not get it in your eyes, nose, mouth, or vagina. You should not use on any other rashes, sores, or cuts. If it does get on these areas, rinse it off right away.

It is important to prevent the tip of the tube from touching the skin ulcer or any other object. This will keep the medicine from being contaminated and a possible source of infection.

To use the gel:

  • Wash your hands before preparing your dose.
  • The proper amount of the gel to be measured depends on the size of the tube you are using and the size of the skin ulcer. You should expect the dose to change each week or every other week, depending on the rate your skin ulcer changes in size.
  • Measure the proper amount carefully onto a clean surface (e.g., wax paper). Close the tube tightly after each use. Then, transfer the medicine to your skin ulcer by using an applicator aid (e.g., a cotton swab, tongue depressor).
  • Spread the medicine on your skin ulcer as a thin (about 1/16 of an inch), even, continuous film.
  • After wetting a gauze pad with 0.9% Sodium Chloride Irrigation USP, apply it on top of your medicated skin ulcer.
  • After 12 hours, remove the medicine left on the skin ulcer with 0.9% Sodium Chloride Irrigation USP or water.
  • Keep the skin ulcer from becoming too dry. When changing the dressing, the existing bandage may need to be wetted with 0.9% Sodium Chloride Irrigation USP to help remove the bandage and prevent injury to the healing skin ulcer.
  • Wet a new gauze pad with 0.9% Sodium Chloride Irrigation USP. Apply it on top of your skin ulcer that no longer has the medicine on it and wait 12 hours before applying the medicine again. Therefore, the medicine is reapplied every 24 hours, with a change in the wound dressing in between applications.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (gel):
    • For skin ulcers caused by type 2 diabetes mellitus:
      • Adults and children 16 years of age and older—Apply to the affected area once a day and leave it on for 12 hours. The amount applied will change each week or every other week, depending on the changing size of the skin ulcer.
      • Children younger than 16 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.


Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

This medicine should not be used after the expiration date. The date can be found at the bottom of the tube.