Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Ankle, knee, or great toe joint pain
  2. joint stiffness or swelling
  3. rash
  4. rash with flat lesions or small raised lesions on the skin


  1. Agitation
  2. ammonia-like breath odor
  3. anxiety
  4. bleeding gums
  5. blistering, peeling, or loosening of the skin
  6. blood in the urine or stools
  7. bloody nose
  8. bloody or black, tarry stools
  9. blue or pale skin
  10. bruising
  11. changes in skin color
  12. chest pain, tightness, or discomfort
  13. chest pain, possibly moving to the left arm, neck, or shoulder
  14. chills
  15. clay-colored stools
  16. cloudy urine
  17. confusion
  18. constipation
  19. cough
  20. coughing up blood
  21. cracks in the skin
  22. dark urine
  23. decreased awareness or responsiveness
  24. decreased urine output
  25. depression
  26. diarrhea
  27. difficulty with breathing
  28. dizziness
  29. drowsiness
  30. dry mouth
  31. feeling of warmth or heat
  32. fever
  33. flushing or redness of the skin, especially on the face and neck
  34. general feeling of discomfort or illness
  35. headache
  36. hives or welts, itching, skin rash
  37. hoarseness
  38. hostility
  39. incoherent speech
  40. increased urination
  41. irritability
  42. joint or muscle pain
  43. large, flat, blue or purplish patches in the skin
  44. light-colored stools
  45. loss of appetite
  46. loss of consciousness
  47. loss of heat from the body
  48. lower back or side pain
  49. metallic taste
  50. muscle twitching or weakness
  51. nausea
  52. noisy breathing
  53. pain, tenderness, or swelling of the foot or leg
  54. painful or difficult urination
  55. pinpoint red or purple spots on the skin
  56. rapid weight gain
  57. red, irritated eyes
  58. red, swollen skin
  59. redness, soreness, or itching skin
  60. right upper abdominal or stomach pain and fullness
  61. scaly skin
  62. seizures
  63. severe sleepiness
  64. severe stomach pain
  65. slow or irregular heartbeat
  66. sore throat
  67. sores, ulcers, or white spots on the lips or in the mouth
  68. sores, welting, or blisters
  69. stomach pain
  70. sweating
  71. swelling of the face, ankles, hands, or lower legs
  72. swollen or painful glands
  73. swollen, painful, or tender lymph glands in the neck, armpit, or groin
  74. thirst
  75. unpleasant breath odor
  76. unusual bleeding or bruising
  77. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  78. unusual weight gain or loss
  79. vomiting
  80. vomiting of blood or material that looks like coffee grounds
  81. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  1. Bad, unusual, or unpleasant (after) taste
  2. blindness
  3. blue-yellow color blindness
  4. blurred vision
  5. body aches or pain
  6. burning feeling in the chest or stomach
  7. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  8. burning, dry, or itching eyes
  9. change in taste
  10. change in vision
  11. congestion
  12. continuing ringing or buzzing or other unexplained noise in the ears
  13. decreased interest in sexual intercourse
  14. decreased vision
  15. difficulty with moving
  16. discharge or excessive tearing
  17. feeling of constant movement of self or surroundings
  18. hair loss or thinning of the hair
  19. hearing loss
  20. impaired vision
  21. inability to have or keep an erection
  22. indigestion
  23. lack or loss of strength
  24. loss in sexual ability, desire, drive, or performance
  25. loss of appetite
  26. loss of memory
  27. multiple swollen and inflamed skin lesions
  28. muscle pain, cramps, stiffness, tenderness, or wasting
  29. problems with memory
  30. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  31. runny nose
  32. sensation of spinning
  33. sensitivity to light
  34. sleepiness or unusual drowsiness
  35. sleeplessness
  36. sneezing
  37. stomach upset
  38. stuffy nose
  39. sweating
  40. swelling of the breasts or breast soreness in both females and males
  41. swelling of the salivary glands
  42. swelling or inflammation of the mouth
  43. tearing
  44. tender, swollen glands in the neck
  45. tenderness in the stomach area
  46. throbbing pain
  47. trouble getting pregnant
  48. trouble with sleeping
  49. trouble with swallowing
  50. unsteadiness or awkwardness
  51. voice changes
  52. weakness in the arms, hands, legs, or feet
  53. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.