Adalimumab (Subcutaneous Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Body aches or pain
2. cough
3. ear congestion
4. gas with stomach pain
5. hoarseness
6. lightheadedness
7. loss of voice
8. lower back or side pain
9. muscle aches and pains
10. pain or tenderness around the eyes or cheekbones
11. rapid and sometimes shallow breathing
12. shivering
13. stomach fullness
14. stuffy nose
15. sunken eyes
16. thirst
17. trouble sleeping
18. warmth on the skin
19. wrinkled skin

Less common

1. Abnormal vaginal bleeding or discharge
2. agitation
3. arm, back, or jaw pain
4. black, tarry stools
5. bleeding from the gums or nose
6. blindness
7. bloating or swelling of the face, arms, hands, lower legs, or feet
8. blood in the stool or change in bowel habits
9. bloody or cloudy urine
10. blurred vision
11. broken bones
12. change in size, shape, or color of an existing mole
13. change in skin color
14. chest pain, tightness, or heaviness
15. chills
16. clear or bloody discharge from the nipple
17. cold hands and feet
18. confusion
19. constipation
20. cough
21. coughing or spitting up blood
22. decreased urination
23. decreased vision
24. depression
25. difficulty with breathing
26. difficulty, burning, or painful urination
27. dimpling of the breast skin
28. dizziness
29. drowsiness
30. eye pain
31. fainting
32. fast, slow, or irregular heartbeat
33. fever
34. forgetfulness
35. frequent urge to urinate
36. general feeling of illness
37. hair loss
38. headache
39. hives, itching, skin rash
40. increased thirst
41. inverted nipple
42. irregular breathing
43. irregular pulse
44. irritability
45. light colored stools
46. loss of appetite
47. lump in the breast or under your arm
48. lump or swelling in the stomach
49. mole that leaks fluid or bleeds
50. muscle cramps or spasms
51. nausea
52. new mole
53. night sweats
54. no blood pressure or pulse
55. noisy breathing
56. numbness or tingling in your arms, legs, or face
57. pain, redness, or swelling in the arms or legs without any injury present
58. pale skin
59. persistent non-healing sore on your skin
60. pink growth
61. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
62. raised, firm, or bright red patch
63. redness or swelling of the breast
64. seeing or hearing things that are not there
65. seizures
66. sharp back pain just below your ribs
67. shiny bump on your skin
68. slurred speech or problems with swallowing
69. sneezing
70. sore on the skin of the breast that does not heal
71. sore throat
72. sores, ulcers, or white spots on the lips or mouth
73. spitting up blood
74. stiff neck
75. stomach pain
76. stopping of the heart
77. sudden high fever or low grade fever for months
78. sweating
79. swelling of the face, fingers, feet, or lower legs
80. swollen glands
81. swollen neck veins
82. tiredness
83. trouble breathing
84. trouble thinking
85. unconsciousness
86. unexplained bruising or bleeding
87. unpleasant breath odor
88. unusual tiredness or weakness
89. unusual weight gain or loss
90. visual disturbances
91. vomiting
92. vomiting of blood or material that looks like coffee grounds
93. yellow skin or eyes

Incidence not known

1. Blistering, peeling, or loosening of the skin
2. diarrhea
3. inability to move the arms and legs
4. joint or muscle pain
5. pinpoint red spots on the skin
6. red skin lesions, often with a purple center
7. red, irritated eyes
8. red, scaling, or crusted skin
9. sudden numbness and weakness in the arms and legs
10. unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Bladder pain
2. bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
3. pounding in the ears

Less common

1. Abnormal healing
2. decrease in height
3. difficulty with moving
4. difficulty with walking
5. dry mouth
6. heartburn
7. indigestion
8. loss of hearing
9. loss of strength or energy
10. menstrual changes
11. muscle or joint stiffness, tightness, or rigidity
12. muscle pain or weakness
13. pain in the back, ribs, arms, or legs
14. shakiness in the legs, arms, hands, and feet
15. swelling or redness in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: Aug. 01, 2023