Melatonin is a hormone in your body that plays a role in sleep. The production and release of melatonin in the brain is connected to time of day, increasing when it's dark and decreasing when it's light. Melatonin production declines with age.
Melatonin is also available as a supplement, typically as an oral tablet. Most melatonin supplements are made in a lab.
People commonly use melatonin for sleep disorders, such as insomnia and jet lag. Unlike with many sleep medications, you are unlikely to become dependent on melatonin, have a diminished response after repeated use (habituation) or experience a hangover effect.
Research on melatonin use for specific conditions shows:
- Circadian rhythm sleep disorders in the blind. Melatonin can help improve these disorders in adults and children.
- Delayed sleep phase (delayed sleep-wake phase sleep disorder). In this disorder your sleep pattern is delayed two hours or more from a conventional sleep pattern, causing you to go to sleep later and wake up later. Research shows that melatonin reduces the length of time needed to fall asleep and advances the start of sleep in young adults and children with this condition.
- Insomnia. Research suggests that melatonin might provide relief from the inability to fall asleep and stay asleep (insomnia) by slightly improving your total sleep time, sleep quality and how long it takes you to fall asleep.
- Jet lag. Evidence shows that melatonin can modestly improve jet lag symptoms, such as alertness.
- Shift work disorder. Some research suggests that melatonin might improve daytime sleep quality and duration in people whose jobs require them to work outside the traditional morning to evening schedule.
- Sleep-wake cycle disturbances. Melatonin can help treat these disturbances in children with a number of disabilities.
Recent research is also exploring whether melatonin might improve cognitive impairment in people with Alzheimer's disease and prevent cell damage associated with amyotrophic lateral sclerosis (ALS).
Your body likely produces enough melatonin for its general needs. However, evidence suggests that melatonin promotes sleep and is safe for short-term use. Melatonin can be used to treat delayed sleep phase and circadian rhythm sleep disorders in the blind and provide some insomnia relief. Treat melatonin as you would any sleeping pill and use it under your doctor's supervision.
Oct. 17, 2017
- Melatonin: In depth. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/melatonin. Accessed Sept. 12, 2017.
- Melatonin. Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed Sept. 12, 2017.
- Ferracioli-Oda E, et al. Meta-analysis: Melatonin for the treatment of primary sleep disorders. PLOS One. 2014;8:e63773.
- Auld F, et al. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Medicine Reviews. 2017;34:10.
- Auger RR, et al. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: Advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An Update for 2015: An American Academy of Sleep Medicine clinical practice guideline. Journal of Clinical Sleep Medicine. 2015;11:1199.
- Melatonin. Facts & Comparisons eAnswers. http://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed Sept. 14, 2017.