Bladder control: Medications for urinary problems
Learn about medications used to treat bladder control problems, including how they work to treat urinary incontinence and possible side effects.By Mayo Clinic Staff
You've given up coffee and soda. You've followed your doctor's suggestions for bladder retraining. But bladder control remains a problem. What else can you do? Ask your doctor about medication options.
Medications are available for people with bladder control problems marked by sudden, intense urinary urges and urine leakage (overactive bladder and urge incontinence). Fewer medication options exist for urine leakage prompted by movement or activity, such as coughing, sneezing or heavy lifting (stress incontinence).
Here's a look at medications commonly prescribed to treat urinary incontinence and their possible side effects. Keep in mind that medication combined with behavioral treatment might be more effective than medication alone.
How they work
Anticholinergic drugs block the action of a chemical messenger — acetylcholine — that sends signals to your brain that trigger abnormal bladder contractions associated with overactive bladder. These bladder contractions can make you feel the need to urinate even when your bladder isn't full.
Anticholinergic medications include:
- Oxybutynin (Ditropan XL, Oxytrol)
- Tolterodine (Detrol)
- Darifenacin (Enablex)
- Solifenacin (Vesicare)
- Fesoterodine (Toviaz)
These medications are usually given as a pill or tablet that you take by mouth. Oxybutynin is also available as a cream or skin patch that delivers a continuous amount of medication.
It can take several weeks before your symptoms begin to improve on this type of medication. It might take 12 weeks to have the full effect.
The most common side effects of anticholinergics are dry mouth and constipation. An extended-release form, which you take once a day, might cause fewer side effects than the immediate-release versions, which are usually taken multiple times a day.
To counteract dry mouth, try sucking hard candy or chewing gum to produce more saliva. Other less common side effects include heartburn, blurry vision, rapid heartbeat (tachycardia), flushed skin, urinary retention and cognitive side effects, such as impaired memory and confusion.
If you use the oxybutynin skin patch, it might cause skin irritation. Your doctor might suggest that you rotate the location of your patch.
How it works
Mirabegron is a medication approved to treat certain types of urinary incontinence. It relaxes the bladder muscle and can increase the amount of urine your bladder can hold. It might also increase the amount you are able to urinate at one time, helping to empty your bladder more completely.
Some common side effects of mirabegron include nausea, diarrhea, constipation, dizziness and headache. It can increase blood pressure, so your blood pressure should be monitored while on this drug.
In addition, it interacts with various medications, so make sure your doctor knows which medications you're taking before you begin taking mirabegron.
Onabotulinumtoxin type A (Botox)
How it works
Injections of Botox into the bladder muscle might benefit people who have an overactive bladder. Botox blocks the actions of acetylcholine and paralyzes the bladder muscle.
Botox might be helpful for people who haven't responded to other medications. Benefits can last several months. Your doctor might recommend repeat injections once or twice a year.
Studies have found that Botox significantly improves symptoms of incontinence and causes few side effects. Some research indicates it may increase urinary tract infections, but the data aren't conclusive.
The Food and Drug Administration (FDA) warns that adverse reactions including respiratory arrest and death may occur after the use of Botox for both approved and unapproved uses.
July 15, 2017
See more In-depth
- Bladder control problems in women (urinary incontinence). National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/urologic-diseases/bladder-control-problems-women. Accessed May 9, 2017.
- Lukacz E. Treatment of urinary incontinence in women. https://www.uptodate.com/home. Accessed May 9, 2017.
- Medical student curriculum: Urinary incontinence. American Urological Association. http://www.auanet.org/education/educational-programs/medical-student-education/medical-student-curriculum/urinary-incontinence. Accessed May 9, 2017.
- Female stress urinary incontinence. National Association for Continence. https://www.nafc.org/womens-stress-urinary-incontinence/?rq=Female%20stress%20urinary%20incontinence. Accessed May 9, 2017.
- Hersh L, et al. Clinical management of urinary incontinence in women. American Family Physician. 2013;87:634.
- DeMaagd GA, et al. Management of urinary incontinence. Pharmacy & Therapeutics. 2012;37:345.
- Highlights of prescribing information: Botox. U.S. Food & Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103000s5232lbl.pdf. Accessed May 16, 2017.
- Imipramine hydrochloride. U.S. Food & Drug Administration. https://google2.fda.gov/search?q=Imipramine+side+effects&client=FDAgov&site=FDAgov&lr=&proxystylesheet=FDAgov&requiredfields=-archive%3AYes&output=xml_no_dtd&getfields=*. Accessed May 16, 2017.