Stages

Stage describes how much cancer there is and how far it has spread. For soft tissue sarcoma, stages generally range from 1 to 4. A lower stage generally means the cancer is more limited. A higher stage means it is more advanced.

Both tumor grade and stage help the healthcare team understand the likely outcome of the condition, called the prognosis, and decide the treatment plan.

Healthcare professionals usually summarize the stage as TNM plus grade. TNM stands for:

  • T: The size and extent of the primary tumor.
  • N: Whether the cancer has spread to nearby lymph nodes.
  • M: Whether the cancer has spread to distant parts of the body.
  • Grade: The grade of the tumor.

Separate staging criteria are used for sarcomas in different areas of the body. Some soft tissue sarcomas do not have staging.

Your care team can explain how your soft tissue sarcoma's stage is described and what that means for you.

Sept. 11, 2026

Living with soft tissue sarcoma?

Connect with others like you for support and answers to your questions in the Sarcoma support group on Mayo Clinic Connect, a patient community.

Sarcoma Discussions

citizendeveloper
FS-DFSP (Fibrosarcomatous dermatofibrosarcoma): Anyone else?

56 Replies Thu, Sep 10, 2026

Colleen Young, Connect Director
Diagnosed with sarcoma? Let's share

1103 Replies Wed, Sep 09, 2026

lessjudd1976
What treatments did you have for angiosarcoma?

10 Replies Tue, Sep 01, 2026

See more discussions
  1. Tyler DS, et al., eds. Sarcomas of the soft tissues, retroperitoneum, and bone. In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 22nd ed. Elsevier; 2026. https://www.clinicalkey.com. Accessed Aug. 21, 2026.
  2. Soft tissue sarcoma. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1464. Accessed Aug. 21, 2026.
  3. Goldman L, et al., eds. Malignant bone tumors, sarcomas, and other soft tissue neoplasms. In: Goldman-Cecil Medicine. 27th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Aug. 21, 2026.
  4. Folpe AL, et al. Enzinger and Weiss's Soft Tissue Tumors. 8th ed. Elsevier; 2027. https://www.clinicalkey.com. Accessed Aug. 21, 2026.
  5. Niederhuber JE, et al., eds. Sarcomas of soft tissue. In: Abeloff's Clinical Oncology. 6th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Sept. 26, 2022.
  6. Soft tissue sarcoma treatment (PDQ) — Patient version. National Cancer Institute. https://www.cancer.gov/types/soft-tissue-sarcoma/patient/adult-soft-tissue-treatment-pdq. Accessed Aug. 21, 2026.
  7. Childhood soft tissue sarcoma treatment (PDQ) — Health professional version. National Cancer Institute. https://www.cancer.gov/types/soft-tissue-sarcoma/hp/child-soft-tissue-treatment-pdq. Accessed Aug. 21, 2026.
  8. Taking time: Support for people with cancer. National Cancer Institute. https://www.cancer.gov/publications/patient-education/taking-time. Accessed Aug. 21, 2026.
  9. Garner HW, et al. ACR Appropriateness Criteria soft tissue masses: 2022 Update. Journal of the American College of Radiology. 2023; doi:10.1016/j.jacr.2023.02.009.
  10. Ami TR. Allscripts EPSi. Mayo Clinic. April 5, 2023.
  11. Sarcoma centers. Sarcoma Alliance. https://sarcomaalliance.org/sarcoma-centers/. Accessed Aug. 21, 2026.
  12. SARC clinical trials. Sarcoma Alliance for Research Through Collaboration. https://sarctrials.org/research/sarc-clinical-trials/. Accessed Aug. 21, 2026.
  13. Roohani S, et al. ESTRO clinical practice guideline on radiotherapy for adult soft tissue sarcoma of the extremities and trunk wall — Endorsed by ASTRO. Radiotherapy and Oncology. 2026; doi:10.1016/j.radonc.2026.111535.
  14. Callegaro D, et al. ASO practice guidelines series: Soft tissue sarcoma of the extremities and superficial trunk. Annals of Surgical Oncology. 2025; doi:10.1245/s10434-025-18223-7.
  15. Soft tissue sarcoma. American Cancer Society. https://www.cancer.org/cancer/types/soft-tissue-sarcoma.html. Accessed Aug. 21, 2026.
  16. Hussein M, et al. Imaging recommendations for soft-tissue sarcomas: Model guidelines from diagnosis to post-treatment follow-up. Clinical Radiology. 2024; doi:10.1016/j.crad.2024.08.023.
  17. Baldini EH, et al. Local control in soft tissue sarcomas. Hematology/Oncology Clinics of North America. 2025; doi:10.1016/j.hoc.2025.04.011.
  18. AskMayoExpert. Malignant soft tissue sarcoma of the extremity: Diagnosis, treatment, and surveillance (adult). Mayo Clinic; 2024.
  19. Soft tissue sarcoma treatment (PDQ): Health professional version. National Cancer Institute. https://www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq. Accessed Aug. 24, 2026.
  20. American College of Surgeons. Soft tissue sarcoma. In: AJCC Cancer Staging System. American College of Surgeons; 2026. https://online.statref.com. Accessed Aug. 24, 2026.
  21. Health Education & Content Services. MC8538-01: Abdominal sarcoma. Mayo Clinic; 2025.
  22. Five things you need to know about sarcoma. Mayo Clinic. https://cancerblog.mayoclinic.org/2024/07/23/five-things-you-need-to-know-about-sarcoma/. Accessed Aug. 26, 2026.
  23. Ryan CW, et al. Clinical presentation, diagnostic evaluation, and staging of soft tissue sarcoma. https://www.uptodate.com/contents/search. Accessed Aug. 26, 2026.
  24. Kaposi sarcoma. American Cancer Society. https://www.cancer.org/cancer/types/kaposi-sarcoma.html. Accessed Aug. 26, 2026.
  25. Skin cancer types: Dermatofibrosarcoma protuberans signs & symptoms. https://www.aad.org/public/diseases/skin-cancer/types/common/dfsp/symptoms. Accessed Aug. 26, 2026.
  26. Soft tissue sarcoma including heart. Surveillance, Epidemiology, and End Results Program. https://seer.cancer.gov/statistics-network/explorer/application.html. Accessed Aug. 25, 2026.
  27. What is cancer? American Cancer Society. https://www.cancer.org/cancer/understanding-cancer/what-is-cancer.html. Accessed Aug. 28, 2026.
  28. Medical review (expert opinion). Mayo Clinic. Sept. 4, 2026.