Stages By Mayo Clinic Staff After confirming a diagnosis of pancreatic cancer, your healthcare team works to find how much cancer is in the body and how far it has spread. This is called the stage of the cancer. To find the stage of pancreatic cancer, the healthcare team typically uses imaging tests such as CT or MRI scans. Endoscopic ultrasound, biopsy results and other test results may provide more information. The staging system below is used for exocrine pancreatic cancers, including pancreatic ductal adenocarcinoma. Health professionals use a different staging system for pancreatic neuroendocrine tumors. For exocrine pancreatic cancer, stage is based on the tumor's size and whether it involves nearby major blood vessels, as well as whether cancer has spread to nearby lymph nodes or other parts of the body. This is called the TNM system. T stands for tumor, N for lymph nodes and M for cancer that has spread to other parts of the body. The stages of exocrine pancreatic cancer include: Stage 0. Cancer cells are found only in the lining of a pancreatic duct. They have not grown into deeper pancreatic tissue or spread to lymph nodes or other parts of the body. Stage 0 also is called carcinoma in situ. Stage 1. The cancer has grown into the tissue of the pancreas and is no larger than 1.5 inches (4 cm). It has not spread to lymph nodes or other organs. Stage 2. The cancer may be larger than 1.5 inches (4 cm) or it may have spread to some nearby lymph nodes. It has not spread to other organs. Stage 3. Cancer has spread to four or more nearby lymph nodes. Or the cancer has grown into major blood vessels near the pancreas. It has not spread to other organs. Stage 4. Cancer has spread to parts of the body farther away from the pancreas. Common places include the liver, the lungs and the lining of the abdomen, also called the peritoneum. Earlier stages mean the cancer is smaller and more limited. Later stages mean it has spread farther, such as to lymph nodes, major blood vessels or distant organs. Knowing the stage helps the healthcare team plan treatment. Surgery may be an option if the cancer can be removed safely. This depends in part on whether the cancer involves nearby blood vessels or has spread to distant organs. Cancer that has spread to distant organs isn't treated with surgery to remove the pancreas. Request an appointment Diagnosis & treatmentSurvival rates Sept. 17, 2026 Share on: FacebookTwitter Living with pancreatic cancer? Connect with others like you for support and answers to your questions in the Pancreatic Cancer support group on Mayo Clinic Connect, a patient community. Pancreatic Cancer Discussions Anyone else on Daraxonrasib (RMC-6236)? 148 Replies Mon, Sep 28, 2026 chevron-right Have you ever had hiccups with or after chemotherapy? 134 Replies Sat, Sep 26, 2026 chevron-right How do I eat after digestive tract surgery? 235 Replies Tue, Sep 22, 2026 chevron-right See more discussions Show references American College of Surgeons. Exocrine pancreas. In: AJCC Cancer Staging System. American College of Surgeons; 2026. https://online.statref.com. Accessed Jan. 30, 2026. Niederhuber JE, et al., eds. Carcinoma of the pancreas. In: Abeloff's Clinical Oncology. 6th ed. Elsevier; 2020. http://www.clinicalkey.com. Accessed March 2, 2026. Pancreatic adenocarcinoma. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1455. Accessed Jan. 30, 2026. Fernandez-del Castillo C, et al. Clinical presentation, diagnosis, and staging of exocrine pancreatic cancer. https://www.uptodate.com/contents/search. Accessed March 2, 2026. AskMayoExpert. Pancreatic cancer (adult). Mayo Clinic; 2023. Canto MI. Familial risk factors for pancreatic cancer and screening of high-risk patients. https://www.uptodate.com/contents/search. Accessed March 2, 2026. Fernandez-del Castillo C, et al. Overview of surgery in the treatment of exocrine pancreatic cancer and prognosis. https://www.uptodate.com/contents/search. Accessed Aug. 21, 2026. Distress management. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=3&id=1431. Accessed Feb. 2, 2026. Sugumar A, et al. Distinguishing pancreatic cancer from autoimmune pancreatitis. Current Gastroenterology Reports. 2010; doi:10.1007/s11894-010-0098-z. Tee MC, et al. Laparoscopic pancreaticoduodenectomy: Is it an effective procedure for pancreatic ductal adenocarcinoma? Advances in Surgery. 2015; doi:10.1016/j.yasu.2015.03.003. NPF Centers of Excellence. National Pancreas Foundation. https://pancreasfoundation.org/patient-resources/npf-centers-of-excellence/. Accessed March 3, 2026. Cancer stat facts: Pancreatic cancer. Surveillance, Epidemiology, and End Results Program, National Cancer Institute. https://seer.cancer.gov/statfacts/html/pancreas.html. Accessed Aug. 21, 2026. Pancreatic cancer: Screening. U.S. Preventive Services Task Force. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/pancreatic-cancer-screening. Accessed Aug. 21, 2026. Hensrud DD, et al., eds. The Mayo Clinic Diet: Weight-Loss Medications Edition. Mayo Clinic Press; 2025. Ruhl JL, et al., eds. Summary Stage 2018: Codes and Coding Instructions. National Cancer Institute; 2025. https://seer.cancer.gov/tools/ssm/2018-Summary-Stage-Manual.pdf. Accessed Aug. 25, 2026. FDA approves first-in-class targeted therapy for metastatic pancreatic cancer. U.S. Food and Drug Administration. Published Aug. 26, 2026. https://www.fda.gov/news-events/press-announcements/fda-approves-first-class-targeted-therapy-metastatic-pancreatic-cancer. Accessed Aug. 26, 2026. Wolpin BM, et al. Daraxonrasib in previously treated advanced RAS-mutated pancreatic cancer. New England Journal of Medicine. 2026; doi:10.1056/NEJMoa2505783. Related Dr. Mark Truty (surgery, MN) better outcomes with chemo Dr. Wallace Video Infographic: Pancreatic Cancer: Minimally Invasive Surgery Infographic: Pancreatic Cancers-Whipple Pancreatic cancer Pancreatic Cancer Survivor Pancreatic ultrasound What is pancreatic cancer? 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