Print Departments and specialties Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. Departments that treat this condition Cancer Care at Mayo Clinic Laboratory Medicine and Pathology Oncology (Medical) Radiation Oncology Radiology Surgery Urology Areas that research this condition Radiology Research Urology Research Doctors who treat this condition Edit search filters close Narrow your search By location Rochester, MN By last name There are no doctors whose last name begins with the letter A A Find a doctor whose last name begins with the letter B B Find a doctor whose last name begins with the letter C C Find a doctor whose last name begins with the letter D D There are no doctors whose last name begins with the letter E E There are no doctors whose last name begins with the letter F F There are no doctors whose last name begins with the letter G G There are no doctors whose last name begins with the letter H H There are no doctors whose last name begins with the letter I I There are no doctors whose last name begins with the letter J J Find a doctor whose last name begins with the letter K K Find a doctor whose last name begins with the letter L L There are no doctors whose last name begins with the letter M M There are no doctors whose last name begins with the letter N N active Find a doctor whose last name begins with the letter O O Find a doctor whose last name begins with the letter P P There are no doctors whose last name begins with the letter Q Q There are no doctors whose last name begins with the letter R R Find a doctor whose last name begins with the letter S S Find a doctor whose last name begins with the letter T T There are no doctors whose last name begins with the letter U U There are no doctors whose last name begins with the letter V V There are no doctors whose last name begins with the letter W W There are no doctors whose last name begins with the letter X X There are no doctors whose last name begins with the letter Y Y Find a doctor whose last name begins with the letter Z Z Reset all filters Search Tips Use quotes for phrases. Even if there are no auto-suggestions within the search field, hit "Search" anyway, as you may still get results. Displaying 1-1 out of 1 doctors available Last Name Initial: O Jacob J. Orme, M.D., Ph.D. Oncologist Rochester, MN Areas of focus: PSMA therapy, Prostate cancer, Bladder cancer, Renal cell carcinoma, Kidney cancer, Testicular cancer, Metastatic bladd...er cancer, Non-muscle invasive bladder cancer Show more areas of focus for Jacob J. Orme, M.D., Ph.D. ResearchMayo Clinic doctors and scientists are helping transform the outlook for people with metastatic bladder cancer through innovative therapies, clinical trials and personalized treatment approaches. Researchers are developing new options that can be tailored to the stage and biology of each person's cancer, with a particular focus on preserving quality of life while improving outcomes. Research led by Mayo Clinic physicians has contributed to advances in immunotherapy, targeted therapies and combination treatments that are expanding options for people with advanced disease. Cancer research is conducted in coordination with Mayo Clinic Comprehensive Cancer Center. Mayo Clinic Comprehensive Cancer Center receives funding from the National Cancer Institute and is designated as a comprehensive cancer center. This designation recognizes the institution's scientific excellence and multidisciplinary resources focused on cancer prevention, diagnosis and treatment. PublicationsSee a list of publications about metastatic bladder cancer by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. Research Profiles Edit search filters close Narrow your search By location Arizona Florida Minnesota View all View all physicians • All Locations Ballman, Karla V. Ph.D. Minnesota Domingo Domenech, Josep M. M.D., Ph.D. Minnesota Pagliaro, Lance C. M.D. Minnesota Zganjar, Andrew J. M.D. Florida By Mayo Clinic Staff Request an appointment Survival rates Sept. 11, 2026 Print Related Associated Procedures Biological therapy for cancer Bladder cancer immunotherapy Bladder cancer radiation therapy Bone scan Cancer treatment Chemotherapy CT scan MRI Palliative care Positron emission tomography (PET) scan Show more associated procedures Metastatic (stage 4) bladder cancerSymptoms&causesDiagnosis&treatmentStagesSurvivalratesDoctors&departments Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. CON-20605858 Diseases & Conditions Metastatic (stage 4) bladder cancer