Print Departments and specialties Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. Departments that treat this condition Colon and Rectal Surgery Early-Onset and Hereditary GI Cancers Program Early-Onset Colorectal Cancer Group Gastroenterology and Hepatology Gastrointestinal Neoplasia Clinic Pediatric Surgery ResearchMayo Clinic doctors and scientists are involved in research to improve understanding, screening and care for people with familial adenomatous polyposis (FAP). Mayo Clinic maintains a Colon Cancer Family Registry that collects data and biospecimens from thousands of families to help identify genes linked to colorectal cancer risk and to understand how genetic changes lead to disease. Researchers examine genetic interactions, biomarkers and other factors that may influence cancer development and prevention. Mayo Clinic researchers also have studied the incidence and risk factors for gastric cancer in people with FAP, aiming to refine surveillance strategies and guide early intervention in rare but serious outcomes. These findings may help shape future recommendations for screening beyond the colon in high-risk patients. Clinical trials at Mayo Clinic have explored potential therapies for FAP, such as study of erlotinib to reduce polyp burden in the upper gastrointestinal tract and investigations into novel agents such as guselkumab to evaluate effects on polyp number and growth. Participation in these trials offers access to emerging approaches under scientific study. PublicationsSee a list of publications about familial adenomatous polyposis (FAP) by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. Research Profiles Edit search filters close Narrow your search By location Arizona Florida Minnesota View all View all physicians • Minnesota Boardman, Lisa A. M.D. Minnesota Cima, Robert R. M.D. Minnesota Dozois, Eric J. M.D. Minnesota Wong Kee Song, Louis M. M.D. Minnesota By Mayo Clinic Staff Familial adenomatous polyposis care at Mayo Clinic Request an appointment Diagnosis & treatmentCare at Mayo Clinic May 12, 2026 Print Living with familial adenomatous polyposis? Connect with others like you for support and answers to your questions in the Colorectal Cancer support group on Mayo Clinic Connect, a patient community. Colorectal Cancer Discussions Worried this might be anal cancer 105 Replies Thu, Jul 30, 2026 chevron-right After colon resection: What helps with severe gas? 49 Replies Thu, Jul 30, 2026 chevron-right Just diagnosed: Surgery not an option, looking for hope 103 Replies Wed, Jul 29, 2026 chevron-right See more discussions Related Associated Procedures Colectomy Ileoanal anastomosis (J-pouch) surgery Ileostomy Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Familial adenomatous polyposisSymptoms&causesDiagnosis&treatmentDoctors&departmentsCare atMayoClinic Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. CON-20372433 Diseases & Conditions Familial adenomatous polyposis