Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production and wheezing. It's caused by long-term exposure to irritating gases or particulate matter, most often from cigarette smoke. People with COPD are at increased risk of developing heart disease, lung cancer and a variety of other conditions.
Emphysema and chronic bronchitis are the two most common conditions that contribute to COPD. Chronic bronchitis is inflammation of the lining of the bronchial tubes, which carry air to and from the air sacs (alveoli) of the lungs. It's characterized by daily cough and mucus (sputum) production.
Emphysema is a condition in which the alveoli at the end of the smallest air passages (bronchioles) of the lungs are destroyed as a result of damaging exposure to cigarette smoke and other irritating gases and particulate matter.
COPD is treatable. With proper management, most people with COPD can achieve good symptom control and quality of life, as well as reduced risk of other associated conditions.
COPD care at Mayo Clinic
Aug. 11, 2017
- What is COPD? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/copd. Accessed Feb. 11, 2016.
- Ferri FF. Chronic obstructive pulmonary disease. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed Feb. 11, 2016.
- Han MK, et al. Chronic obstructive pulmonary disease: Definition, clinical manifestations, diagnosis, and staging. http://www.uptodate.com/home. Accessed Feb. 15, 2016.
- Balkissoon R, et al. Chronic obstructive pulmonary disease: A concise review. Medical Clinics of North America. 2011;95:1125.
- Foreman M, et al. Genes and COPD. Medical Clinics of North America. 2012;96:699.
- Longo DL, et al., eds. Chronic obstructive pulmonary disease. In: Harrison's Principles of Internal Medicine. 19th ed. New York, N.Y.: McGraw-Hill Education; 2015. http://www.accessmedicine.com. Accessed Feb. 15, 2016.
- Pagon RA, et al., eds. Alpha-1 antitrypsin deficiency. In: GeneReviews. Seattle, Wash.: University of Seattle, Washington; 1993-2016. http://www.ncbi.nlm.nih.gov/books/NBK1116. Accessed March 23, 2016.
- Hillas G, et al. Managing comorbidities in COPD. International Journal of Chronic Obstructive Pulmonary Disease. 2015;10:95.
- Standards for the diagnosis and management of patients with COPD. American Thoracic Society. http://www.thoracic.org/copd-guidelines/index.php. Accessed March 23, 2016.
- Ferguson GT, et al. Management of stable chronic obstructive pulmonary disease. http://www.uptodate.com/home. Accessed Feb. 15, 2016.
- Barbara Woodward Lips Patient Education Center. Chronic obstructive pulmonary disease (COPD). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
- Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. March 22, 2016.
- Stoller JK. Management of exacerbations of chronic obstructive pulmonary disease. http://www.uptodate.com/home. Accessed March 23, 2016.
- Mallea JM (expert opinion). Mayo Clinic, Jacksonville, Fla. April 26, 2016.
- What are the benefits of quitting smoking? National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/health-topics/topics/smo/benefits. Accessed April 27, 2016.
- Jha P, et al. 21st-century hazards of smoking and benefits of cessation in the United States. The New England Journal of Medicine. 2013;368:341.