Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Outcomes of Open and Endovascular Repair for Ruptured and Non-Ruptured Internal Iliac Artery Aneurysms

   Rochester, Minn.

   The purpose of this study is to evaluate different techniques to repair internal iliac artery aneurysms. Report short and long term clinical outcomes with markers of pelvic perfustion.  Compare partial pelvic perfusion preservation with bilateral complete preservation.

2. A Study to Explore Ghrelin Levels with Primary Graft Dysfunction in Lung Transplant Recipients

   Jacksonville, Fla.

   The purpose of this study is to investigate ghrelin, a peptide that mechanistically carries the promise of therapeutics benefit for diverse aspects of morbidity associated with lung transplantation.

3. A Study to Assess Sinus Stenting to Manage Cerebrospinal Fluid Leak

   Rochester, Minn.

   The purpose of this study is to determine whether transverse/sigmoid sinus junction stenting reduces the risk of recurrent cerebrospinal fluid (CSF) leak in patients with idiopathic intracranial hypertension presenting with CSF leak.

    

4. A Study to Analyze Gender Congruence After Gender Confirmation Surgery

   Rochester, Minn.

   The purpose of this study is to assess the success and effectiveness of gender confirmation surgeries on eliminating gender incongruence and improving life satisfaction, and compare patient’s status with the preoperative results.

5. A Study of Mesenchymal Stem Cell (MSC) Adherence and Vessel Wall Penetration Following Intra-arterial Delivery Subsequent to Controlled Balloon Angioplasty

   Jacksonville, Fla.

   The purpose of this study is to determine the amount of MSCs that adhere to predetermined areas of arterial wall following balloon angioplasty vs no intervention, and to characterize the effect of intra-arterial injection of MSCs on predetermined areas of arterial wall via transcriptome analysis.

6. A Study to Evaluate the Process of Aging in Human Atherosclerosis

   Rochester, Minn.

   The purpose of this study is to critically test the hypothesis that senescent-cell derived factors (cell aging), in particular IGFBP3, suppress the innate repair capacity of vascular smooth muscle cells (VSMC) in human atherosclerosis.

7. A Study to Evaluate Biomarker Target Stimulation

   Rochester, Minn.

   The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.

8. The Use of Topical Tranexamic Acid in Implant-Based Breast Reconstruction with Acellular Dermal Matrix

   Rochester, Minn.

   The purpose of this study is to determine whether administration of Topical Transexamic Acid (TXA) at the time of tissue expander placement in the setting of implant-based breast reconstruction reduces postoperative drain volume, as well as reducing the time until drains meet criteria for removal.

    

9. Genomic and Environmental Basis of Imperforate Anus

   Rochester, Minn.

   The study aims are to develop a consent-based IRB proposal that will enroll newborns who have imperforate anus.  The proposal will include permission for chart review and database information storage, to develop a database that will include MRN, imperforate anus phenotype, information on other congenital malformations, syndromic diagnosis if available, demographic information, and to develop a biobank of DNA and white blood cell samples from infants with imperforate anus. If patients are undergoing a skin biopsy for a medically indicated reason, cells will be requested.

   Imperforate Anus, also known as anal atresia, is a rare birth defect.  Unable to pass stool through the gastrointestinal tract, this condition can result in death of the newborn and emergency surgery is required once discovered.  More than two thirds of affected infants have other birth defects that include other parts of the gastrointestinal tract, airway, heart, skeleton, kidneys, eyes, or ears. The exact prevalence of imperforate anus in the newborn population is unknown. 

10. Brachial plexus patients undergoing upper limb amputation

    Rochester, Minn.

    The purpose of this study is to follow Mayo Clinic patients with severe brachial plexus injuries who underwent upper limb amputation.