Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study of the Ability to Predict Lymphedema Development Following Axillary Surgery for Breast Cancer and Its Effects on Patient Survivorship

   Jacksonville, Fla.

   The purpose of this study is to better understand the anatomy of the lymphatic structure and the molecular process that leads to the over production of lymph fluid.  This proposal will begin intense lymphedema screening and identify baseline characteristics potentially predisposing someone to lymphedema, and identify molecular markers that might be altered to prevent lymphedema. 

2. Study Of Zanzalintinib In Combination With Immuno-Oncology Agents In Participants With Solid Tumors

   Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz.

   This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, pharmacokinetics (PK), preliminary antitumor activity, and effect of biomarkers of zanzalintinib administered alone, and in combination with nivolumab (doublet), nivolumab + ipilimumab (triplet) and nivolumab + relatlimab (triplet) in participants with advanced solid tumors.
   
   In the Expansion Stage, the safety and efficacy of zanzalintinib as monotherapy and in combination therapy will be further evaluated in tumor-specific Expansion Cohorts.

3. A Study to Develop Processes for Tissue Growth for Use in Reconstruction Surgeries

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to develop the procedures for the growth of specific cells and tissues needed for reconstruction surgeries of the head and neck using the waste tissues of other surgeries.

4. Cerebral Spinal Fluid Evaluation in Individuals Who Have Idiopathic Normal Pressure Hydrocephalus (INPH)

   Rochester, Minn.

   The purpose of this study is to further characterize the serum and Cerebral Spinal Fluid (CSF) biomarker profile of idiopathic normal pressure hydrocephalus, both before and after VP shunt placement, and help differentiate this profile from Alzheimer’s disease.

    

5. Clinical Outcomes of Patients Treated With Open Surgical Repair for Complex Aortic Aneurysms

   Rochester, Minn.

   This is a prospective, non-randomized, single center, data collection study of patients treated with open surgical repair (OR) for complex aortic aneurysms (CAAs).

6. A Study of Blood Clotting Response in Patients with a Traumatic Injury

   Rochester, Minn.

   The purpose of this study is to look at the blood’s clotting response in people who have suffered a traumatic injury and compare it with non-injured people.

7. Does the Critical Shoulder Angle Influence the Rotator Cuff Failure After Anatomic Shoulder Arthroplasty?

   Rochester, Minn.

   The purpose of this study is to:

   • Evaluate the influence of the critical shoulder angle (CSA) on outcomes after total anatomic shoulder arthroplasty; and
   • Evaluate the influence of the critical shoulder angle (CSA) on rotator cuff failure after total anatomic shoulder arthroplasty.

8. A Study Of CGM In GBM

   Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.

   The purpose of this study is to compare standard glucose monitoring versus continuous glucose monitoring (CGM) with endocrinology-guided intervention in newly diagnosed glioblastoma (GBM) patients receiving standard-of-care therapy.

9. Defining The Immunologic Profile Of Sentinel Lymph Nodes And Identifying The Mechanisms Responsible For Immunosuppression

   Jacksonville, Fla., Rochester, Minn.

   The purpose of this study is to look at the effects cancer and melanoma have on the immune cells found in lymph nodes.

10. A Study to Evaluate Preiser's Disease and Its Complications

    Rochester, Minn.

    The purpose of this study is to describe the outcome and complications in surgical management of Preiser',s disease in the past 30 years in the Mayo Clinic.