Clinical trials Below are current clinical trials.21 studies in Kidney Transplant Program (open studies only). Filter this list of studies by location, status and more. Concomitant Renal and Urinary Bladder Allograft Transplantation Rochester, Minn. Patients that need reconstruction or re-building of their urinary bladder are often limited to having a segment of their intestine used for that purpose. Using intestine is less than ideal as it is an absorptive, mucous producing tissue and placing this in constant contact with urine creates significant long term problems. In patients that require a kidney transplant and bladder reconstruction, this study seeks to use a bladder graft from a deceased donor rather than intestine. A Study of Study of Immune Tolerance Mechanisms in Kidney Transplant Patients Scottsdale/Phoenix, Ariz. Hypothesis: we hypothesize that the abundance and functions of Breg subsets in kidney transplant patients could be associated with transplant tolerance and rejection, including DSA-mediated kidney transplant rejection. In addition, oral corticosteroid treatment significantly alters the frequency and function of Breg subsets, which could lead altered clinical outcomes. Aims, purpose, or objectives: 1. Investigate the frequency Bregs and their ability to express IL-10 along with other immune cells in the context of tolerance/rejection in kidney transplant patients. we hypothesize that the abundance and functions of Breg subsets in kidney transplant patients could be associated with transplant tolerance and rejection, including DSA-mediated kidney transplant rejection. 2.Investigate the frequency and functions of Bregs along with other immune cells in the setting of long term corticosteroid use. We hypothesize that oral corticosteroid treatment significantly alters the frequency and function of Breg subsets, which could lead altered clinical outcomes. A Study to Assess the Updated Prospera™ Diagnostic Test Scottsdale/Phoenix, Ariz. The purpose of this study to collect blood samples and data to assess the diagnostic capability of an updated version of the Prospera™ test. The current standard of care for detection of rejection in renal allograft recipients is serum creatinine, often used in combination with other blood tests such as proteinuria. Natera has developed an assay called Prospera™ to detect the amount of donor-derived cell-free DNA (dd-cfDNA), which is a marker of kidney rejection. A Study to Assess Reproductive History in Kidney Donors Rochester, Minn., Scottsdale/Phoenix, Ariz. The purpose of this study is to analyze the effect of parity, menopause and reproductive lifespan on kidney structure and function. A Study to Evaluate Alloantibody Titer in Highly Sensitized Kidney Transplant Candidates Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz. The purpose of this study is to evaluate the utility of using anti-HLA antibody titer to measure the effectiveness of antibody lowering therapy (i.e., desensitization) in highly-sensitized kidney transplant candidates. Tissue and Blood Registry for Individuals with Liver and Biliary Tumors Jacksonville, Fla. This study will collect and store samples of tissue and blood for current and future research studies on Liver and Biliary Tumors. A Study to Evaluate Ultrasound Imaging in Renal Transplant Recipients Jacksonville, Fla. The purpose of this study is to determine the effectiveness of ultrasound elastography in prediction of renal allograft fibrosis. A Study to Examine Diabetes Control and Patient Reported Outcomes Among Kidney Transplant Recipients with Type 2 Diabetes Rochester, Minn. This study aims to measure the percentage of time spent in hyperglycemia in patients on insulin therapy and evaluate diabetes related patient reported outcomes in kidney transplant recipients with type 2 diabetes. It also aimes to evaluate immunosuppression related patient reported outcomes in kidney transplant recipients with type 2 diabetes. Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients Rochester, Minn. The aim of this study is to determine the validity of two tests on bone marrow of sensitized kidney transplant recipients in order to better understand why these patients with antibodies against their donors are at a greater risk of rejection of their transplanted organs. Ultrasound Microvessel Imaging of Transplant Kidney Rochester, Minn. The purpose of this study is to investigate the value of ultrasound microvessel imaging for evaluation of transplant kidney health. Pagination Clinical studies Go to page 11 Go to page 22 Go to page 33 NextNext Page Request an appointment Locations, travel & lodgingResearch May 09, 2023 Share on: FacebookTwitter Kidney Transplant ProgramDepartmenthomeSectionsRequest an appointmentOverviewConditions treatedDoctorsDoctors by location and specialtyExpertise & rankingsLocations, travel & lodgingClinical trialsResearchPatient storiesCosts & insuranceNews from Mayo ClinicVolumes and outcomesEligibilityReferralsContactus Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. SectionsRequest an appointmentOverviewConditions treatedDoctorsDoctors by location and specialtyExpertise & rankingsLocations, travel & lodgingClinical trialsResearchPatient storiesCosts & insuranceNews from Mayo ClinicVolumes and outcomesEligibilityReferrals ORG-20193489 Medical Departments & Centers Kidney Transplant Program