Mayo Clinic's Aerospace Medicine program supports aviation safety by providing comprehensive care, specialized aeromedical consulting, biomedical research, and education for businesses and individuals within the aviation industry, as well as other specialized programs for aviation personnel and passengers on the ground and in the air.

The Aerospace Medicine program offers a comprehensive range of services, including:

The Federal Aviation Administration (FAA) trains and certifies the Aviation Medical Examiner (AME). The FAA has designated certain Mayo physicians with a minimum of three years of accurately performing flight physicals as Senior Aviation Medical Examiners (SAMEs). SAMEs are qualified to perform Class I examinations, which meet the standard for commercial airline transport pilots.

Mayo Clinic also features several aviation medical examiners who are trained in providing care to pilots requiring surveillance in the Human Intervention and Motivation Study (HIMS). This surveillance is required for certain pilots with prior substance abuse issues or aviators prescribed antidepressant medications monitored by the Federal Air Surgeon's Office.