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    2002-2021SARS/MERS

    History of SARS/MERS: Outbreaks and vaccine timeline

    Learn about SARS, MERS and vaccine research.

    SARS/MERS
    SARS

    Severe acute respiratory syndrome coronavirus (SARS-CoV), which causes SARS

    2002-2003

    Severe acute respiratory syndrome coronavirus (SARS-CoV), which causes SARS, is found in China. From late 2002 to late 2003, it causes about 8,000 illnesses and 700 deaths. It spreads to 29 countries and then it disappears. Researchers continue to study and develop vaccines for SARS-CoV.

    2012

    Middle East respiratory syndrome coronavirus (MERS-CoV), which causes MERS, is found in Saudi Arabia. It has caused about 2,500 cases and 800 deaths. Many researchers continue to study and develop vaccines for MERS-CoV.

    1. Plotkin SA, et al., eds. Plotkin’s Vaccines. 7th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Oct. 8, 2021.
    2. Blake JB. Benjamin Waterhouse and the introduction of vaccination. Reviews of Infectious Diseases. Oxford University Press. 1987;doi:10.1093/clinids/9.5.1044.
    3. Desmond A, et al. On the shoulders of giants — From Jenner's cowpox to mRNA Covid vaccines. The New England Journal of Medicine. 2021; doi:10.1056/NEJMp2034334.
    4. Saleh A, et al. Vaccine development throughout history. Cureus. 2021; doi:10.7759/cureus.16635.
    5. The history of vaccines. College of Physicians of Philadelphia. https://www.historyofvaccines.org. Accessed Oct. 7, 2021.
    6. Stokes J, et al. Trivalent combined measles-mumps-rubella vaccine. JAMA. 1971;218:57.
    7. Klein NP. Licensed pertussis vaccine in the United States: History and current state. 2014; doi:10.4161/hv.29576.
    8. Influenza historic timeline. Centers for Disease Control and Prevention. https:// archive.cdc.gov/#/details?url=https://www.cdc.gov/flu/pandemic-resources/pandemic-timeline-1930-and-beyond.htm. Accessed Nov. 14, 2024.
    9. Poland GA, et al. Development of vaccines against Zika virus. The Lancet. Infectious Diseases. 2018; doi:10.1016/S1473-3099(18)30063-X.
    10. Poland GA, et al. Zika vaccine development: Current status. Mayo Clinic Proceedings. 2019; doi:10.1016/j.mayocp.2019.05.016.
    11. Li YD, et al. Coronavirus vaccine development: From SARS and MERS to COVID-19. Journal of Biomedical Science. 2020; doi:10.1186/s12929-020-00695-2.
    12. Dolgin E. The tangled history of mRNA vaccines. Nature. 2021; doi:10.1038/d41586-021-02483-w.
    13. Goodman RA, et al., eds. Vaccination mandates: The public health imperative and individual rights. In: Law in Public Health Practice. Oxford University Press; 2007.
    14. Centers for Disease Control and Prevention. Current trends childhood immunization initiative, United States — 5-year follow up. MMWR Morbidity and Mortality Weekly Report. 1982; http://www.cdc.gov/mmwr/preview/mmwrhtml/00001091.htm. Accessed Oct. 7, 2021.
    15. Vaccination. Office of Disease Prevention and Health Promotion. https:// odphp.health.gov/healthypeople/objectives-and-data/browse-objectives/vaccination. Accessed Nov. 13, 2024.
    16. The history of vaccines. History of the immunization schedule. College of Physicians of Philadelphia. https:// historyofvaccines.org/activities/history-immunization-schedule. Accessed Nov. 13, 2024.
    17. NCIRD national surveillance materials and resources. Centers for Disease Control and Prevention. https:// www.cdc.gov/ncird-surveillance/resources/?CDC_AAref_Val=https://www.cdc.gov/ncird/surveillance/materials-resources.html. Accessed Nov. 13, 2024.
    18. Roush SW, et al. Historical comparisons of morbidity and mortality for vaccine-preventable disease in the United States. JAMA. 2007; doi:10.1001/jama.298.18.2155.
    19. Poland GA (expert opinion). Mayo Clinic. Sept. 17, 2021.
    20. Benefits of the flu vaccine. Centers for Disease Control and Prevention. https:// www.cdc.gov/flu-vaccines-work/benefits/?CDC_AAref_Val=https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm. Accessed Nov. 13, 2024.
    21. 1918 pandemic influenza timeline. Centers for Disease Control and Prevention. https://archive.cdc.gov/#/details?archive_url=https://archive.cdc.gov/www_cdc_gov/flu/pandemic-resources/1918-commemoration/pandemic-timeline-1918.htm. Accessed Nov. 14, 2024.
    22. Safety of COVID-19 vaccines. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/safety-of-vaccines.html. Accessed Oct. 8, 2021.
    23. COVID-19 vaccine basics. Centers for Disease Control and Prevention. https:// www.cdc.gov/covid/vaccines/how-they-work.html#cdc_vaccine_basics_types-types-of-vaccines. Accessed Nov. 20, 2024.
    24. COVID-19 vaccines. U.S. Food and Drug Administration. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-vaccines. Accessed Dec. 2, 2024.
    25. Poland GA, et al. The age-old struggle against the antivaccinationists. The New England Journal of Medicine. 2011; doi:10.1056/NEJMp1010594.
    26. Clapesattle H. The Doctors Mayo. The University of Minnesota Press; 1941.
    27. Saint Mary's isolation hospital during the influenza pandemic. Saint Marys Hospital Annals; 1918.
    28. Harren R. Olmsted County in the grippe of Spanish influenza. The Scribe. History Center of Olmsted Country. 2018.
    29. Strand PK. A century of caring: 1889-1989. Saint Marys Hospital; 1988.
    30. Mayo Clinic: The battle plan for H1N1. Mayo Alumni Magazine; 2009.
    31. First polio vaccine delivery. MayoVox. Mayo Clinic; 1955.
    32. Rosenow EC. Prophylactic inoculation against respiratory infections during the present pandemic of influenza: Preliminary report. Mayo Clinic; 1918.
    33. Rules concerning the report of contagious diseases. The Clinic Bulletin. 1919;1;1.
    34. Maltezou HA, et al. Immunization of health-care providers: Necessity and public-health policies. Healthcare. 2016; doi:10.3390/healthcare4030047.
    35. Voigt EA, et al. Defending against smallpox: A focus on vaccines. Expert Review of Vaccines. 2016; doi:10.1080/14760584.2016.1175305.
    36. Wright GH, et al. Effect of reduced dose schedules and intramuscular injection of anthrax vaccine adsorbed on immunological response and safety profile: A randomized trial. Vaccine. 2014; doi:10.1016/j.vaccine.2013.10.039.
    37. Spikevax. U.S. Food and Drug Administration. https:// www.fda.gov/vaccines-blood-biologics/spikevax. Accessed Dec. 2, 2024.
    38. Infectious Disease. Office of Disease Prevention and Health Promotion. https:// odphp.health.gov/healthypeople/objectives-and-data/browse-objectives/infectious-disease. Accessed Nov. 13, 2024.
    39. Coronavirus disease (COVID-19). World Health Organization. https://www.who.int/news-room/fact-sheets/detail/coronavirus-disease-(covid-19). Accessed Nov. 27, 2024.
    40. FDA approves and authorizes updated mRNA COVID-19 vaccines to better protect against currently circulating variants. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-and-authorizes-updated-mrna-covid-19-vaccines-better-protect-against-currently. Accessed Dec. 6, 2024.

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