Mateo G. Leon, M.D.

Dr. Mateo Leon is a complex benign gynecologist and minimally invasive gynecologic surgeon at Mayo Clinic in Jacksonville, Florida. He provides compassionate, patient-centered care for patients who come to Mayo Clinic from throughout Florida and across the Southeastern United States, with a focus on improving quality of life through precision medicine.

Dr. Leon completed a fellowship in Minimally Invasive Gynecologic Surgery at Mayo Clinic and is dedicated to offering advanced treatment options that help patients return to their daily lives as comfortably and quickly as possible. He is especially mindful that many patients he sees have often been living with symptoms for years and are seeking not just treatment, but also clarity and long-term relief.

His clinical expertise includes fertility-sparing procedures, endometriosis surgery with advanced excision techniques to address chronic pain, uterus-sparing fibroid removal (myomectomy), treatment of chronic pelvic pain using multidisciplinary approaches, and minimally invasive hysterectomy performed through laparoscopic and robotic techniques.

Dr. Leon's approach prioritizes listening carefully, identifying the underlying cause of symptoms, and developing a treatment plan that supports both immediate relief and long-term well-being. He offers a full range of advanced minimally invasive procedures, with the goal of helping patients access effective care while avoiding open surgery whenever possible.

He serves as a regional referral expert for complex endometriosis, fibroid surgery, and minimally invasive gynecologic procedures, caring for patients from across the Southeast and beyond who seek advanced expertise for challenging or persistent gynecologic conditions.

"I believe healing starts with truly listening," says Dr. Leon. "I seek to understand each patient's symptoms, concerns, and goals, and then we can work together to build a personalized treatment plan to support recovery, comfort and long-term quality of life."

When not practicing medicine, Dr. Leon likes to follow soccer, hang out with his family and pursue a multitude of water sports.