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John R. Giudicessi, M.D., Ph.D.

  1. Cardiologist

Specialty Groups


  1. Rochester, Minnesota



A native of Des Moines, Iowa, Dr. John Giudicessi, M.D., Ph.D., completed his undergraduate studies at Lawrence University in Appleton, Wisconsin. After receiving his doctoral degrees from the Mayo Clinic Alix School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences in 2014, he went on to complete a residency in Internal Medicine, post-doctoral research fellowship in cardiovascular genetics under the mentorship of Dr. Michael J. Ackerman, M.D., Ph.D., and a clinical fellowship in Cardiovascular Diseases as part of the Mayo Clinic Clinician-Investigation Training Program. The recipient of the 2021 Mayo Clinic Alumni Association Donald C. Balfour Award for Meritorious Research, Dr. Giudicessi's translational research efforts aim to utilize multiomics- and artificial intelligence-aided approaches to improve the diagnosis, risk-stratification and clinical management of patients with sudden cardiac death-predisposing inherited cardiac channelopathies and cardiomyopathies. Clinically, Dr. Giudicessi has an active outpatient practice and sees patients in Mayo Clinic's Cardiac Sarcoidosis, Cardiomyopathy, and Genetic Heart Rhythm Clinics.

  1. Arrhythmogenic right ventricular cardiomyopathy
  2. Brugada syndrome
  3. Cardiac sarcoidosis
  4. Catecholaminergic polymorphic ventricular tachycardia
  5. Hypertrophic cardiomyopathy
  6. Long QT syndrome
  7. Short QT syndrome
  8. Sudden cardiac arrest
  9. Ventricular fibrillation
  • Acquired and congenital long QT syndrome
  • Arrhythmogenic cardiomyopathies
  • Artificial intelligence
  • Cardiac channelopathies
  • Circulating biomarker discovery
  • Genetic modifier discovery
  • Inflammatory cardiomyopathies
  • Polygenic risk scores in rare disease
  • Rare variant resolution
  1. 2021
    FellowCardiovascular Disease, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. 2021
    Post Doctoral FellowshipClinician-Investigator Training Program, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. 2017
    ResidencyInternal Medicine Residency, Mayo School of Graduate Medical Education, Mayo Clinic in Rochester
  4. 2017
    ResidentInternal Medicine, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  5. 2014
    Doctor of MedicineMayo Medical School, Mayo Clinic College of Medicine
  6. 2014
    Doctor of PhilosophyMolecular Pharmacology and Experimental Therapeutics, Mayo Graduate School, Mayo Clinic College of Medicine


  1. 2021
    Cardiovascular DiseasesAmerican Board of Internal Medicine
  2. 2017
    Internal MedicineAmerican Board of Internal Medicine

Awards and honors

  1. 2023
    Mayo Clinic Experience Top Performer AwardMayo Clinic Office of Patient Experience
  2. 2022
    Paul and Ruby Tsai and Family Career Development Award in Hypertrophic Cardiomyopathy Research Honoring Dr. Nishimura.Mayo Clinic
  3. 2022
    Mayo Clinic Proceedings Highly Cited Author AwardMayo Clinic Proceedings
  4. 2021
    Cardiovascular Diseases Fellowship Outstanding Research AwardMayo Clinic
  5. 2021
    Donald C. Balfour Alumni Award for Meritorious ResearchMayo Clinic Alumni Association
  6. 2018
    National Human Genome Research Institute Scholarship AwardKeystone Symposia
  7. 2018
    Brandt Family Early Career Investigator Scholarship AwardMayo Clinic Center for Individualized Medicine
  8. 2017
    Council on Genomic and Precision Medicine Early Career Investigator Travel GrantAmerican Heart Association
  9. 2013
    Featured New Investigator DesignationCentral Society for Clinical and Translational Research
  10. 2012
    Trainee Travel AwardCentral Society for Clinical and Translational Research
  11. 2012
    Scholar AwardAmerican Federation of Clinical Research
  12. 2011
    Ruth L. Kirchstein National Research Service AwardNational Heart Lung and Blood Institute
  13. 2005
    Howard and Helen Russell Award for Excellence in Biological ResearchLawrence University
  14. 2005
    John M. Walter Scholastic AwardBeta Theta Pi
  15. 2002
    Dr. Arnold and Dorothy Rohr Pre-Medical ScholarshipLawrence University
  16. 2001
    Merit ScholarshipLawrence University

Professional memberships

  1. 2022 - present
    MemberMayo Clinic MSTP (MD/PhD Program) Admissions Committee
  2. 2018 - present
    MemberAmerican College of Cardiology
  3. 2018 - present
    MemberEuropean Society of Cardiology
  4. 2018 - present
    MemberHeart Rhythm Society
  5. 2010 - present
    Member, Council on Genomic and Precision MedicineAmerican Heart Association
  6. 2007 - present
    MemberAmerican Physician Scientists Association (APSA)
  7. 2006 - present
    MemberAmerican Medical Association