Herbert C. Wolfsen, M.D.

Herbert C. Wolfsen, M.D., is a consultant in the Division of Gastroenterology and Hepatology, Department of Medicine at Mayo Clinic in Florida. He joined the staff of Mayo Clinic in 1995 and holds the academic rank of Professor of Medicine and Science.

Dr. Wolfsen earned his Diploma of Doctor of Medicine from Loma Linda University School of Medicine in California. He completed his residency at Virginia Mason Medical Center in Seattle, WA in 1990. After serving as an internist, he completed a fellowship in gastroenterology and hepatology at the Mayo Clinic in Rochester, MN in 1993.

Dr. Wolfsen's academic career has focused on the development and optimized utilization of endoscopic techniques for the detection and treatment of Barrett's dysplasia and early esophageal adenocarcinoma and squamous cell carcinoma. This work has included advanced imaging studies using technology such as high definition white light imaging, narrow band imaging, confocal laser endomicroscopy, spectroscopy (fluorescent, light scattering and diffuse reflectance) and volumetric endomicroscopy (optical Fourier domain imaging). These techniques hold promise for innovative screening and surveillance strategies. The development of minimally invasive endoscopic treatment modalities has included mucosal resection and ablation technologies such as photodynamic therapy, radiofrequency ablation and cryotherapy using liquid nitrogen spray and carbon dioxide. In addition to developmental studies, comparative outcome analysis of these advanced imaging and ablation methods is a focus of current research.