概述

骨质疏松症导致骨变弱和变脆,在跌倒时甚至是轻微压力下(如弯腰或咳嗽)都可能导致骨折。骨质疏松症相关骨折最常见于髋部、腕部或脊柱。

骨是不断被分解和替换的活组织。当形成的新骨少于被替换的旧骨时,会发生骨质疏松症。

骨质疏松症影响所有种族的男性和女性。但白人和亚裔女性(尤其是已经绝经的年长女性)的风险最高。药物、健康饮食和负重运动有助于防止骨量丢失或增强业已脆弱的骨。

症状

骨量丢失的早期阶段通常没有症状。但一旦您的骨骼因骨质疏松症而变得脆弱,您可能会出现以下体征和症状:

  • 背痛,由于脊柱骨折或塌陷引起。
  • 身高逐渐减少。
  • 呈弯腰姿势。
  • 骨骼比预期更容易骨折。

何时就诊

如果您绝经提前或服用皮质类固醇数月,或者您的父亲或母亲发生过髋部骨折,您可能需要咨询医务人员您是否患有骨质疏松症。

病因

您的骨处于不断更新的状态,新骨生成和旧骨破坏。当您年轻时,身体生成新骨的速度快于破坏旧骨的速度,因此骨量增加。在 20 岁左右,该过程放缓,大多数人到 30 岁时达到骨量峰值。随着年龄增长,骨量流失的速度快于骨生成的速度。

罹患骨质疏松症的可能性一定程度上取决于年轻时获得的骨量。骨量峰值一部分由遗传决定,不同的种族之间也有差异。您的骨量峰值越高,您“储存”的骨越多,随着年龄增长患上骨质疏松症的可能性也越低。

风险因素

许多因素会增加患骨质疏松症的可能性,包括年龄、种族、生活方式选择和医疗状况与治疗。

不可改变的风险

有些导致骨质疏松症的风险因素无法控制,包括:

  • 性别。女性比男性更容易患骨质疏松症。
  • 年龄。年龄越大,患骨质疏松症的风险越大。
  • 种族。白人或亚裔患骨质疏松症的风险最大。
  • 家族病史。父母或兄弟姐妹患有骨质疏松症会使您患病的风险更大,尤其是如果您的母亲或父亲发生过髋部骨折。
  • 体型。身材矮小的男性和女性往往有较高的患病风险,因为随着年龄增长,这类人群的骨量可能会减少。

激素水平

骨质疏松症在体内某些激素过多或过少的人中更为常见。示例包括:

  • 性激素。性激素水平的降低往往会导致骨骼衰弱。绝经女性雌激素含量的下降是最有可能引发骨质疏松症的风险因素之一。对降低男性睾酮含量的前列腺癌的治疗以及对降低女性雌激素含量的乳腺癌的治疗可能会加速骨量丢失。
  • 甲状腺问题。过多的甲状腺激素会导致骨量丢失。如果您的甲状腺过度活跃或服用过多的甲状腺激素药物来治疗甲状腺功能低下,则会发生这种情况。
  • 其他腺体。骨质疏松症的病因还包括甲状旁腺和肾上腺过度活跃。

饮食因素

存在以下状况的人群更容易发生骨质疏松症:

  • 钙摄入量低。终身缺钙是出现骨质疏松症的一项促成因素。钙摄入量低会导致骨密度下降、提前出现骨量丢失并导致骨折风险增加。
  • 进食障碍。严格限制饮食以及体重过轻都会减弱男性和女性的骨强度。
  • 胃肠道手术。缩小胃部或切除部分肠道的手术会限制可用于吸收营养物质(包括钙)的表面积,包括可以帮助减轻体重以及治疗其他胃肠道疾病的手术。

类固醇和其他药物。

长期口服或注射泼尼松和可的松等皮质类固醇药物,会干扰骨重建过程。骨质疏松症也与用于治疗或预防的药物有关:

  • 癫痫发作。
  • 胃反流检查。
  • 癌症。
  • 移植排斥。

医疗问题

有某些医疗问题的人患骨质疏松症的风险更高,包括:

  • 乳糜泻。
  • 炎性肠病。
  • 肾病或肝病。
  • 癌症。
  • 多发性骨髓瘤。
  • 类风湿关节炎。

生活方式的选择

有些坏习惯可能增加患骨质疏松症的风险。示例包括:

  • 久坐生活方式。久坐者患骨质疏松症的风险高于活动量较大的人。任何负重运动以及促进平衡和良好姿势的活动都对您的骨骼有益,但是行走、跑步、跳跃、跳舞和举重似乎尤其有用。
  • 过度饮酒。长期每天饮用超过两杯酒精饮料会增加患骨质疏松症的风险。
  • 烟草使用。烟草在骨质疏松症中起到的确切作用尚不明确,但是事实表明烟草使用会导致骨变脆弱。

并发症

骨折(特别是脊柱或髋关节骨折)是骨质疏松症最严重的并发症。髋部骨折通常由跌倒引起,可能导致失能,甚至会增加损伤后第一年发生死亡的风险。

脊柱骨折在某些情况下即使人没有跌倒,也有可能发生。组成脊柱的骨头(椎骨)可能弱化甚至塌陷,这会导致背痛、身高变矮和向前弓背。

预防

Keep Your Bones Healthy

While nearly everyone will lose bone over the course of their lifetime, there are several steps you can take to keep your bones healthy.

Matthew T. Drake, M.D., Ph.D.: Welcome to the Mayo Clinic. My name is Dr. Matthew Drake. I am one of the doctors who works in the Endocrine Clinic, where I provide care to patients with skeletal related issues. Bone loss occurs in both men and women with aging but can also occur for other reasons such as medications or lifestyle factors. While nearly everyone will lose bone over the course of their lifetime, there are several simple steps you can take to help maintain a strong skeleton and to limit your risk for having a broken bone.

Over the next several minutes, we will review some general ways in which you can optimize your bone health. These include making good choices to limit your risk of having a fall. Using good technique when lifting to avoid having a back fracture. Staying active with regular weight bearing activities such as walking. And ensuring you get enough calcium and vitamin D. Beyond these important factors which you can control, you and your provider may decide it is best to take a medication to limit your risk for bone loss and fractures. This question and others can be discussed with your provider today during your appointment. Remember, keeping your bones healthy and preventing fractures are important things for all adults. We hope the information you will view over the next several minutes will help you to better understand your own bone health and ways in which you can keep yourself fracture free in the future.

Woman: Bone loss occurs with aging in all adults. This can lead to osteopenia, which is moderate bone loss, or osteoporosis, which is severe bone loss. In both conditions, bones become thinner and more porous due to the loss of minerals stored in the bones.

Osteopenia and osteoporosis are usually painless until a bone breaks or fractures. These fractures usually occur in the spine, hip, or wrist, but can happen in other bones as well. Without medical treatment, men and women lose 1 to 3% of their bone mass each year over the age of 50. As bone strength or density decreases, people are much more likely to develop osteoporosis or have fractures.

Osteoporosis may develop over many years. As you age, you are more likely to develop osteoporosis. Loss of estrogen in women due to menopause, and lower testosterone levels in men also increase bone loss. Women who experience early menopause or have their ovaries removed at a younger age are more likely to have increased bone loss. Some medications, drinking too much alcohol, and smoking may also increase your risk.

People who have taken medications that are bad for the bone, have hypogonadism, have had a transplant, or have had a weight loss surgery, are more likely to have rapid bone loss. There are many other risk factors for osteoporosis, including a family history of osteoporosis, Caucasian or Asian descent, a small body frame or low dietary intake of calcium or vitamin D.

To help you have strong bones and prevent or slow bone loss as you age, there are two main things to focus on, keeping your bones healthy and preventing fractures. Everyone can take steps to help keep bones strong and healthy throughout life. You can start today. The top five things to keep your bones healthy are, being active or exercising, eating calcium rich foods, getting enough vitamin D, stopping smoking and limiting alcohol.

Exercise helps strengthen bones, slows bone loss, and improves fitness. Aim for 30 to 60 minutes a day with a combination of weight bearing, aerobic, muscle strengthening, and non-impact exercises. Weight bearing exercises are activities done while on your feet with your bones supporting your weight. Some of these types of exercises include walking, jogging, and dancing. Tai Chi is a good example of non-impact exercise. Talk to your doctor about what exercise may be best for your situation.

It is best to get calcium from your food rather than a pill. Dairy products, certain green vegetables such as spinach, broccoli, or kale, and calcium fortified fruit juices and soy beverages contain good amounts of calcium. Generally, the goal is to get at least three servings per day from your diet. You may have to take a calcium supplement if you are not getting enough calcium from your diet. Supplements are absorbed well, are typically inexpensive, and are easy to take. If you take a calcium supplement, it is best to combine it with vitamin D.

Vitamin D is important for calcium absorption and maintaining bone health. Vitamin D is normally made in the skin with enough sun exposure but is also found in some foods and vitamin supplements. Ask your health care provider for more information about how much vitamin D you need and what to do about supplements.

If you smoke, stop. Smoking increases your risk for osteopenia and osteoporosis. Alcohol use can also increase your risk for developing osteoporosis. Limit alcohol intake to one drink a day if you are a woman, and two drinks a day if you are a man.

You can help prevent fractures. The two main things you can do to help are avoiding falls and taking medications. Falls are the number one risk factor for fractures. Take steps to prevent falls in your home, have well-lit rooms and hallways. Do not climb ladders, keep electrical and phone cords out of the walkways, and remove rugs when possible.

Be careful of activities that put you at risk for fractures, such as lifting too much weight and snow shoveling. Use proper lifting technique and talk to your doctor about your specific lifting restrictions.

Several types of medication may prevent further loss of bone density by up to 5 to 10%. This can significantly reduce the risk of a fracture. Most osteoporosis medications can help stop bone loss. Other medications help build bone formation. Your provider can help you decide which treatment may be best for you.

Matthew T. Drake, M.D., Ph.D.: Osteoporosis and osteopenia are common conditions affecting over half of all people 50 years of age and older in the United States. It's often without symptoms until a bone breaks or someone develops deformity of the spine. Think about how many people you know, who have suffered a fracture and how it affected their life. Breaking a bone can be prevented. First, make sure you're getting enough calcium between diet and supplements. For most with osteoporosis or osteopenia, this will be around 1,200 milligrams.

The problem is, is that the average dietary calcium intake for people 50 years of age or older is half of what's recommended. Several studies have shown that calcium, combined with low daily doses of vitamin D reduces fracture risk and increases bone density.

Vitamin D is also important to help you absorb calcium efficiently. Vitamin D deficiency is very common, especially as you age. Weight bearing exercise combined with strengthening, also helps keep your bone strong. However, for some people who are at high risk, taking calcium and vitamin D along with exercise isn't enough to prevent fractures. Your provider may recommend taking medication in addition to calcium and vitamin D.

If your risk is high enough for fracture, then the benefits of taking medication will almost always outweigh the risks associated with medications. Your provider and pharmacist can review medication use with you. Remember, as you age, your risk for falls goes up, too. Most fractures occur after a fall. Did you know that 5% of falls result in a fracture, 10% result in serious injury, and 30% result in any type of injury? Don't fall. I often tell my patients if it looks like a bad idea, it probably is a bad idea. Do you really need to climb the ladder to remove the leaves from the gutter or can someone else help you? Do you really need to leave the light off, so you don't disturb your husband when you go to the bathroom in the middle of the night? Make sure your home is safe for you.

Balance exercises such as Tai Chi have also been shown to prevent falls if you do them at least twice a week. Keeping your bones healthy and preventing fractures are important for everyone as they age. I hope this information helps you and your bones stay healthy in the years to come.

Woman: If you have any questions about this information, talk with your healthcare provider.

营养充足和运动规律对保持骨健康至关重要。

18 至 50 岁的男性和女性每天需要 1,000 毫克的钙。当女性年满 50 岁、男性年满 70 岁时,每日所需钙量会增加至 1,200 毫克。

良好的钙来源包括:

  • 低脂乳制品。
  • 深绿叶蔬菜。
  • 带骨的三文鱼或沙丁鱼罐头。
  • 豆制品,如豆腐。
  • 加钙谷物和橙汁。

如果您难以从饮食中摄取足够的钙,可以考虑服用钙补充剂。然而,钙过多会与肾结石产生关联。尽管尚不清楚,但一些专家认为摄入过多的钙,尤其是通过补充剂摄入,可能会增加患心脏病的风险。

美国国家科学、工程和医学学院的健康与医学部建议,50 岁以上的人每天从补充剂和饮食中摄入的钙总量不应超过 2000 毫克。

维生素 D

维生素 D 能够提高人体对钙的吸收能力,并从其他方面改善骨骼健康。人体可以从阳光中获取部分维生素 D,但如果您生活在高纬度地区、如果您难以出门,或者如果您因为皮肤癌的风险而经常使用防晒霜或避免晒太阳,这一来源可能并不合适。

维生素 D 的膳食来源包括鱼肝油、鳟鱼和鲑鱼。许多种类的牛奶和谷物都添加了维生素 D。

大多数人每天至少需要 600 国际单位(IU)的维生素 D。对于 70 岁及以上的成年人,建议增加到 800 IU

没有其他维生素 D 来源的人,尤其是接触阳光有限的人,可能需要补充维生素 D。大多数复合维生素产品都含有 600 至 800 IU 的维生素 D。对于大多数人来说,每天摄入最多 4,000 IU 的维生素 D 是安全的。

运动

运动可帮助您骨骼强健,同时减缓骨质流失。不管何时开始,运动都会使您的骨骼受益,如果您年轻时就开始定期锻炼,并终身持续,您会得到最大获益。

将力量训练运动与负重和平衡运动相结合。力量训练有助于增强手臂和上脊柱的肌肉和骨骼。负重运动 - 如行走、慢跑、跑步、爬楼梯、跳绳、滑雪和产生冲击的运动 - 主要影响腿部、髋关节和下脊柱的骨骼。尤其随着年龄增长,平衡运动(例如太极)可减少跌倒的风险。

Feb. 24, 2024
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