Radiation therapy for breast cancer

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Displaying 1-1 out of 1 doctors available

Last Name Initial: L

  1. James L. Leenstra, M.D.

    James L. Leenstra, M.D.

    1. Radiation Oncologist
    Areas of focus:

    Cancer treatment, Radiation therapy for breast cancer, Stereotactic body radiotherapy, Radiation therapy for prostate c...ancer, Electron beam radiotherapy, Prostate cancer, Breast cancer, Head and neck cancer, Lung cancer

Research

Radiation therapist and dosimetrist

Mayo Clinic doctors and scientists are dedicated to advancing radiation therapy treatment options for people with breast cancer. This research is conducted as part of the Mayo Clinic Cancer Center. Mayo Clinic is one of the few medical centers recognized as a Specialized Program of Research Excellence (SPORE) for breast cancer research, funded by the U.S. National Cancer Institute.

Areas of research include:

  • Developing new ways to reduce exposure to healthy tissues, including pioneering proton therapy techniques.
  • Advancing evidence-based hypofractionated radiation schedules, including one-week treatment approaches designed to reduce treatment burden while maintaining excellent cancer outcomes.
  • Combining surgeries for lumpectomy and brachytherapy in a way that safely shortens treatment.
  • Evaluating shorter radiation schedules, techniques to protect the heart and lungs, and approaches that personalize treatment intensity according to a patient's risk of recurrence.
  • Leading important clinical trials that aim to improve patient outcomes.

Learn more about cancer research at Mayo Clinic, including clinical trials for new radiation therapy approaches to breast cancer treatment.

Publications

See a list of publications about breast cancer by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

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By Mayo Clinic Staff

Radiation therapy for breast cancer care at Mayo Clinic

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AboutCare at Mayo Clinic
Aug. 14, 2026
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  1. Radiation therapy for breast cancer. National Cancer Institute. https://www.cancer.gov/types/breast/treatment/radiation. Accessed July 23, 2026.
  2. Breast cancer treatment (PDQ) — Health professional version. National Cancer Institute. https://www.cancer.gov/types/breast/hp/breast-treatment-pdq. Accessed July 23, 2026.
  3. Shaitelman SF, et al. Partial breast irradiation for patients with early-stage invasive breast cancer or ductal carcinoma in situ: An ASTRO clinical practice guideline. Practical Radiation Oncology. 2024; doi:10.1016/j.prro.2023.11.001.
  4. Jimenez RB, et al. Postmastectomy radiation therapy: An ASTRO/ASCO/SSO clinical practice guideline. Practical Radiation Oncology. 2025; doi:10.1016/j.prro.2025.05.001.
  5. Smith BD, et al. Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology evidence-based guideline. Practical Radiation Oncology. 2018; doi:10.1016/j.prro.2018.01.012.
  6. Brunt AM, et al. Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 10-year efficacy and late normal tissue effects from a multicentre, open-label, non-inferiority, phase 3, randomised controlled trial and 5-year efficacy results from a randomised axillary substudy. The Lancet. 2026; doi:10.1016/S1470-2045(26)00076-8.
  7. Behroozian T, et al. Multinational Association of Supportive Care in Cancer clinical practice guidelines for the prevention and management of acute radiation dermatitis: International Delphi consensus-based recommendations. The Lancet Oncology. 2023; doi:10.1016/S1470-2045(23)00067-0.
  8. Behroozian T, et al. MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: Part 1, systematic review. eClinicalMedicine. 2023; doi:10.1016/j.eclinm.2023.101886.
  9. Breast reconstruction after mastectomy. National Cancer Institute. https://www.cancer.gov/types/breast/treatment/surgery/breast-reconstruction. Accessed July 23, 2026.
  10. Belkacemi Y, et al. Post-mastectomy radiation therapy after breast reconstruction: From historic dogmas to practical expert agreements based on a large literature review of surgical and radiation therapy considerations. Critical Reviews in Oncology/Hematology. 2024; doi:10.1016/j.critrevonc.2024.104421.
  11. Mutter RW, et al. Proton therapy for breast cancer: A consensus statement from the Particle Therapy Cooperative Group Breast Cancer Subcommittee. International Journal of Radiation Oncology, Biology, Physics. 2021; doi:10.1016/j.ijrobp.2021.05.110.
  12. Lu Y, et al. Comparison of deep inspiration breath hold versus free breathing in radiotherapy for left-sided breast cancer. Frontiers in Oncology. 2022; doi:10.3389/fonc.2022.845037.
  13. External beam radiation therapy for cancer. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/radiation-therapy/external-beam. Accessed July 23, 2026.
  14. Nausea and vomiting and cancer treatment. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/side-effects/nausea-vomiting. Accessed July 23, 2026.
  15. Kunkler IH, et al. Breast-conserving surgery with or without irradiation in early breast cancer. New England Journal of Medicine. 2023; doi:10.1056/NEJMoa2207586.
  16. Alcorn S, et al. External beam radiation therapy for palliation of symptomatic bone metastases: An ASTRO clinical practice guideline. Practical Radiation Oncology. 2024; doi:10.1016/j.prro.2024.04.018.
  17. Medical review (expert opinion). Mayo Clinic. Aug. 10, 2026.

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