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Mayo Clinic researchers are studying ways to improve the effectiveness of prostate brachytherapy.

The effectiveness of permanent prostate brachytherapy depends on how the radioactive seeds are distributed. Researchers at Mayo Clinic study imaging techniques to improve the results of permanent prostate brachytherapy treatment. They have conducted tests on human tissue that produce clear, 3D images of the prostate within a few minutes.


Vibro-acoustography uses high-energy sound waves (ultrasound) to cause tissue to vibrate. Cancerous tissue is harder (denser) than normal tissue, and vibro-acoustography is particularly sensitive to hard objects. Vibro-acoustography makes it possible to place brachytherapy seeds, check their position and correct placement in one procedure.


See a list of publications about permanent prostate brachytherapy by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

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Jan. 13, 2022
  1. Prostate cancer. National Comprehensive Cancer Network. Accessed Oct. 3, 2019.
  2. Wein AJ, et al., eds. Radiation therapy for prostate cancer. In: Campbell-Walsh Urology. 11th ed. Elsevier; 2016. Accessed Oct. 2, 2019.
  3. What is brachytherapy? American Brachytherapy Society. Accessed Oct. 3, 2019.
  4. Bekelman, JE, et al. Clinically localized prostate cancer: ASCO clinical practice guidelines endorsement of an American Urological Association/American Society for Radiation Oncology/Society of Urologic Oncology guideline. Journal of Clinical Oncology. 2018; doi:10.1200/JCO.18.00606.
  5. Zoarsky NG, et al. The evolution of brachytherapy for prostate cancer. Nature Reviews Urology. 2017; doi:10.1038/nrurol.2017.76.
  6. Brachytherapy. Accessed Oct. 3, 2019.
  7. Roach M, et al. Brachytherapy for low-risk or favorable intermediate-risk, clinically localized prostate cancer. Accessed Oct. 16, 2019.
  8. Alizad A, et al. Application of vibro-acoustography in prostate tissue imaging. Medical Physics. 2013; doi:10.1118/1.4773890.
  9. Davis BJ, et al. American Brachytherapy Society consensus guidelines for transrectal ultrasound-guided permanent prostate brachytherapy. Brachytherapy. 2012; doi:10.1016/j.brachy.2011.07.005.
  10. Yamada, Y, et al. American Brachytherapy Society consensus guidelines for high-dose-rate prostate brachytherapy. Brachytherapy. 2012; doi:10.1016/j.brachy.2011.09.008.
  11. Wong WW (expert opinion). Mayo Clinic. Feb. 14, 2020.

Prostate brachytherapy