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DNA damage and chromosome breaks.
Incorrect repair of DNA double-strand breaks can join the wrong DNA ends together, and cause DNA translocations.
In parallel, they developed vertebrate transposon tools including protein trap gene-breaking vectors to generate a collection of more than 1,000 molecularly characterized and revertible mutant zebrafish lines.
Study of communication and negotiating styles of physicians, tacit reasoning, and using uncertainty principles, breaking bad news.
Current studies in his laboratory concentrate on the mechanisms of action of several DNA double-strand break repair proteins, including 53BP1 and BRCA1-BARD1, and on understanding the contribution of chromatin dynamics to the DNA dam...
Mohni's laboratory uses DNA double strand break repair assays, checkpoint signaling, quantitative proteomics and single molecule assays to study how HHVs manipulate the DNA damage response.
Lancaster directly visualizes T and B cells as they interact within their organ microenvironments in order to understand how communication within the immune system breaks down with age.
Sussman is examining phosphodiesterases — proteins that break down cAMP — and their interacting proteins to explore their effects on kidney cyst formation and to better understand the cellular pathways that promote cyst f...
Lucchinetti also led ground-breaking research describing for the first-time evidence for inflammatory cortical demyelination in early MS .
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