Search Results 31-40 of 8485 for TNF

  1. T Cells in Rheumatoid Arthritis Have Damaged Mitochondria, Study Finds - Mayo Clinic News Network

    "For the last 25 years, tumor necrosis factor has been an important therapeutic target to treat autoimmune disease and tissue inflammation," says Mayo Clinic ...

  2. Xiaogang Li, Ph.D. - Mayo Clinic Faculty Profiles

    Focus areas · Epigenetics and PKD . · TNF-alpha and inflammatory signaling in PKD . · Understanding the mechanisms of cilium biogenesis. · Gene therapy in ADPKD .

  3. A Study to Assess Therapeutic Hypothermia to Cool Injured Legs in Patients with Acute Respiratory Distress Syndrome - Mayo Clinic

    ... TNF receptor 1 or Fas, greatly accelerated apoptosis, which was detectable within 30 minutes and was associated with accelerated activation of caspase-2, -8 ...

  4. Liver Pathobiology Lab: Gregory J. Gores - Mayo Clinic Research

    The lab is examining the hypothesis that ductular reactive cells induce macrophage TNF-related apoptosis-inducing ligand (TRAIL) expression as a counter- ...

  5. Head-to-head comparison between vedolizumab and adalimumab for treatment of moderately to severely active ulcerative colitis - Mayo Clinic

    The Food and Drug Administration approved the use of anti-tumor necrosis factor and anti-integrin agents for the treatment of ulcerative colitis in 2005 ...

  6. A Study to Establish An Integrated Biomarker Panel for COVID-19 Infection Risk and Severity Prediction - Mayo Clinic

    Hypothesis: Baseline cytokine (IL-1β, IL-6, IL-4, IL-10, IFN-g and TNF-a) and the immune cellular repertoire (helper/CD4+, cytotoxic/CD8+, T-regulatory ...

  7. Citrullinated Antigens in Rheumatoid Arthritis Patient-Matched Synovial Biopsy, Synovial Fluid, and Serum Samples - Mayo Clinic

    ... TNF-inhibitors. Correlate local levels of antigen with systemic levels measured in serum using matched patient tissue and blood sample, and correlate local ...

  8. Jin-San Zhang, Ph.D. - Mayo Clinic Faculty Profiles

    The NF-kappa B activation is also responsible for tumor necrosis factor-alpha (TNF-alpha) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand ( ...

  9. Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab and Pegylated Liposomal Doxorubicin as Treatment for Ovarian Cancer. (PROTA) - Mayo Clinic

    ... tumor necrosis factor alpha (TNFa) and interleukin-2 (IL-2). These cytokines result in immunological danger signaling and multiple appealing T-cell effects ...

  10. Advances in the treatment of Crohn's disease and ulcerative colitis - Mayo Clinic

    New medications. The immunology of IBD is very complex, and drug targeting is complex. Within the United States, four anti-TNF agents are currently approved for ...