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1. Phase 2 Trial Of Adagrasib Monotherapy And In Combination With Pembrolizumab And A Phase 3 Trial Of Adagrasib In Combination In Patients With A KRAS G12C Mutation KRYSTAL-7 - Mayo Clinic

   The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with ...

2. Efficacy And Safety Study Of Benralizumab To Reduce OCS Use In Patients With Uncontrolled Asthma On High Dose Inhaled Corticosteroid Plus LABA And Chronic OCS Therapy - Mayo Clinic

   The purpose of this trial is to confirm if benralizumab can reduce OCS dependence (after dose optimisation) in patients who are uncontrolled on high-dose ICS- ...

3. A Study To Evaluate Firstline Pembrolizumab Alone Or In Combination With Pemetrexed And Carboplatin In Induction/Maintenance Or Postprogression In Treating Patients With Stage IV Non-squamous Non-small Cell Lung Cancer - Mayo Clinic

   Drugs used in chemotherapy, such as pemetrexed and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by ...

4. The Partner II Trial: A Study Of The Placement Of Aortic Transcatheter Valves - Mayo Clinic

   The purpose of this trial is to determine the safety and effectiveness of the Edwards SAPIEN XT and the Edwards SAPIEN 3 transcatheter heart valve and delivery ...

5. A Study Evaluating Deep Brain Stimulation for Treating Parkinson's Patients with Insomnia - Mayo Clinic

   About this study. The purpose of this study is to evaluate the safety, and feasibility of adjuvant high frequency stimulation of the GPe using Deep Brain ...

6. Transfemoral Replacement Of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial - Mayo Clinic

   The purpose of this study is to evaluate the safety and performance of the HLT System in patients with severe aortic stenosis who present at High Risk for ...

7. A Study To Evaluate The Treatment Of Lumbar Spinal Stenosis (LSS) With The MILD Procedure - Mayo Clinic

   The purpose of this study is to examine functional improvement in lumbar spinal stenosis (LSS) patients with neurogenic claudication who are treated with the ...

8. Pazopanib In Treating Patients With Metastatic Non-Clear Cell Kidney Cancer - Mayo Clinic

   Pazopanib hydrochloride may also stop the growth of kidney cancer by blocking blood flow to the tumor. Participation eligibility. Participant eligibility ...

9. A Dose Titration Study To Assess The Effects Of SAR407899 In Patients With Microvascular Angina And/or Persistent Stable Angina Despite Angiographically Successful Elective PCI - Mayo Clinic

   - To assess SAR407899 plasma concentrations in microvascular angina patients and/or persistent stable angina despite angiographically successful elective PCI.

10. Ixazomib Plus Pomalidomide And Dexamethasone In Treating Patients With Relapsed Or Relapsed/Refractory Multiple Myeloma - Mayo Clinic

    Giving ixazomib with pomalidomide and dexamethasone may be an effective treatment for relapsed or relapsed/refractory multiple myeloma. Participation ...