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  1. Alisertib in Treating Patients With Advanced or Metastatic Sarcoma - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  2. A Study To Compare The Effectiveness, Safety And Tolerability Of P1101 Vs. Anagrelide For Essential Thrombocythemia - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  3. A Study Of The Efficacy And Safety Of Upadacitinib (ABT-494) In Subjects With Moderately To Severely Active Crohn's Disease Who Have Inadequately Responded To Or Are Intolerant To Conventional Therapies But Have Not Failed Biologic Therapy - Mayo Clinic

    The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and ...

  4. A Study To Evaluate Abemaciclib To Treat Advanced Bone And Soft Tissue Sarcoma Identified As Having CDK Pathway Alteration - Mayo Clinic

    The purpose of this study is to evaluate the 12-week progression free survival (PFS) rate in treated subjects, based on historical sarcoma trial outcomes (PFS ...

  5. A Phase 3 Study To Examine The Effectiveness, Safety And Tolerability Of APL-130277 For The Acute Treatment Of Motor Fluctuation Episodes In Patients With Parkinson's Disease - Mayo Clinic

    A Phase 3 Study To Examine The Effectiveness, Safety And Tolerability Of APL-130277 For The Acute Treatment Of Motor Fluctuation Episodes In Patients With ...

  6. Study Of INCB053914 In Subjects With Advanced Malignancies - Mayo Clinic

    About this study. This is an open-label, dose-escalation study of the proviral integration site of Moloney murine leukemia virus (PIM) kinase inhibitor ...

  7. Nedosiran In Pediatric Patients From Birth To 5 Years Of Age With PH And Relatively Intact Renal Function - Mayo Clinic

    About this study. The purpose of this study is to evaluate the safety, effectiveness, and pharmacokinetics (PK, how a drug is metabolized by the body) of ...

  8. A Study To Evaluate The Efficacy And Safety Of Ruxolitinib Cream In Participants With Cutaneous Lichen Planus - Mayo Clinic

    The purpose of this study is to establish the effectiveness of ruxolitinib 1.5% cream BID (twice daily) in participants with cutaneous lichen planus (LP).

  9. Observational Multicenter Case-control Study to Assess Nailfold Capillary Abnormalities in Systemic Lupus Erythematosus - Mayo Clinic

    The purpose of this study is to investigate the role of nailfold capillaroscopy in the assessment of patients with Systemic Lupus Erythematosus (SLE).

  10. Z-Endoxifen Hydrochloride in Treating Patients with Metastatic or Locally Recurrent Estrogen Receptor-Positive Breast Cancer - Mayo Clinic

    Hormone therapy using Z-endoxifen hydrochloride may fight breast cancer by blocking the use of estrogen by tumor cells. Participation eligibility. Participant ...