Clinical Trials Below are current clinical trials.101 studies in Pulmonary, Critical Care, and Sleep Medicine (open studies only). Filter this list of studies by location, status and more. A Study to Evaluate Convalescent Plasma to Stem Coronavirus Scottsdale/Phoenix, Ariz. The purpose of this study is to assess the effectiveness and safety of Human coronavirus immune plasma (HCIP) to reduce the risk of hospitalization or death, the duration of symptoms and duration of nasopharyngeal or oropharyngeal viral shedding. A Study to Assess Neuromuscular Ultrasound to Predict the Duration of Mechanical Ventilation. Rochester, Minn. The purpose of this study is to evaluate whether or not the diaphragm and abdominal muscle thickness determine the duration of mechanical ventilation in adult critically ill patients. A Study to Evaluate RheOx Bronchial Rheoplasty System to Treat Chronic Bronchitis in Adults with COPD Jacksonville, Fla., Rochester, Minn. The purpose of this study is to assess the safety and effectiveness of Bronchial Rheoplasty for the treatment of the symptoms of chronic bronchitis in adult COPD patients with moderate to severe chronic bronchitis. A Study to Evaluate Immunotherapy for Non-Small Cell Lung Cancer Scottsdale/Phoenix, Ariz. The primary objectives of this study are to evaluate safety/tolerability and immunogenicity of IMU-201 as monotherapy and in combination with an immune checkpoint inhibitor (ICI) or an ICI and chemotherapy in participants with advanced NSCLC tumors that are positive for PD-L1, and to identify the Optimal Biological Dose (OBD) of IMU-201 as monotherapy and in combination with an ICI, or an ICI and chemotherapy, in participants with advanced NSCLC tumors that are positive for PD-L1. A Study to Analyze Potential Long-term Treatments for Covid-19 Recovery Rochester, Minn., Scottsdale/Phoenix, Ariz. This study aims to further understand the extent of long term effects of COVID-19 via batteries of self-assessment questionnaires focused on the most common complications of SARS-COVID 19 infections including respiratory and cardiovascular symptoms, frailty, fatigue, exercise capacity, cognitive and emotional functionality, and overall quality of life. Furthermore, we will investigate the impact of 4 weeks of respiratory muscle training and nasal breathing on the above mentioned long-term Covid-19 disease complications. A Dose Escalation Study of Amivantamab in Participants with Advanced Non-Small Cell Lung Cancer Rochester, Minn. The purpose of this study is to evaluate the safety and pharmacokinetics, establish a recommended phase 2 dose (RP2D) regimen, and to assess the preliminary effectiveness of JNJ-61186372 in participants with advanced non-small cell lung cancer (NSCLC). A Study to Compare Transverse Diagnostic Methods in Pediatric Patients After Polysomnogram for Diagnosis of Obstructive Sleep Apnea Rochester, Minn. The primary purpose of this study is to analyze maxillary transverse dimensions in children who have completed polysomnography (PSG), using McNamara’s Criteria and Andrew’s Six Elements. A Study to Evaluate a Health and Wellness Coaching Model in Support of Caregivers of Patients with Advanced Lung Cancers Jacksonville, Fla. Piloting the BeWell360-CG model, in conjunction with usual care delivery for lung cancer patients in Palliative Care, will longitudinally improve the wellbeing and quality of life of care givers within and outside of clinical care settings, in such a way as to positively impact the quality of care of patients themselves. We hypothesize that PC staff trained in the BeWell360-CG will be able to identify the most common CG-centric needs and guide CGs to improve their QoL and personal wellbeing. In doing so, we further hypothesize that there will be an improvement in patient-reported and quality of care outcomes. The objective of this proposal is to pilot a novel, scalable, user-friendly HWC care model– the BeWell360-CG— that is embedded and integrated as part of a palliative approach to care for CGs of patients with advanced lung cancer. Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of JAB-3312 Based Combination Therapies in Adult Patients with Advanced Solid Tumors Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz. The purpose of this study is to demonstrate the safety and tolerability of JAB-3312 in combination with anti-PD-1 mAb or MEKi or KRASi or EGFR-TKI in patients with advanced solid tumors. A Study To Evaluate the Effect of Canakinumab or Pembrolizumab Given as Monotherapy or in Combination as Neo-adjuvant Treatment for Subjects With Early Stages NSCLC Scottsdale/Phoenix, Ariz. The purpose of this study is to evaluate the effect of canakinumab or pembrolizumab as monotherapy or combined as neo-adjuvant treatment for subjects with early stage non-small cell lung cancer. Pagination Clinical studies Go to page 11 Go to page 22 Go to page 33 Go to page 44 Go to page 55 NextNext Page Medical Professionals Pulmonary, Critical Care, & Sleep Medicine Clinical Trials