Clinical Trials Below are current clinical trials.120 studies in Neurology and Neurosurgery (open studies only). Filter this list of studies by location, status and more. A Study Of A New Way To Treat Children And Young Adults With A Brain Tumor Called NGGCT Rochester, Minn. The purpose of this study is to monitor outcome to ensure that children and young adults with localized central nervous system (CNS) non-germinomatous germ cell tumors (NGGCT) treated with Induction chemotherapy followed by response evaluation and whole ventricular + spinal canal irradiation (WVSCI) will maintain the excellent 2-year progression free survival (PFS) rate as compared to ACNS0122. Also, to improve disease control by decreasing the number of spinal relapses for patients who achieve a complete response (CR) or partial response (PR) and receive WVSCI as compared to whole ventricular radiation on ACNS1123. A Study to Assess Sinus Stenting to Manage Cerebrospinal Fluid Leak Rochester, Minn. The purpose of this study is to determine whether transverse/sigmoid sinus junction stenting reduces the risk of recurrent cerebrospinal fluid (CSF) leak in patients with idiopathic intracranial hypertension presenting with CSF leak. Magnetic Resonance Elastography of Traumatic Brain Injury Rochester, Minn. This purpose of this pilot study is to determine if there are changes in mild TBI detectible with MRE. This is the first time this novel technology has been applied to mild TBI and the anticipated results are theoretical. Resting State Connectivity in Adolescents with Postural Orthostatic Tachycardia Syndrome and Chronic Pain Rochester, Minn. The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings. Sex-Specific Effects Of Endocrine Disruption On Aging And Alzheimer's Disease Jacksonville, Fla., Rochester, Minn. The researchers are trying to determine whether ovarian hormones are associated with aging processes and with the risk of developing Alzheimer's disease in women. Creation of PLACENTA/Serum Repository Database: Autoimmunity from Mother To Baby Study Rochester, Minn. The purpose of the study is to learn more about autoimmunity and potential mother to baby transmission of pathogenic antibodies. The collected research samples from children will be frozen and stored at the Mayo Clinic and will be used for future studies of autoimmune diseases. A Multimodal Monitoring (MMM) Computer to Detect Physiologic Trends in Data in Neurointensive Care Unit Patients Rochester, Minn., Jacksonville, Fla. The purpose of this study is to identify important physiologic trends in bedside ICU data such as cerebral perfusion pressure (CPP), intracranial pressure (ICP) using a bedside “Multimodal monitoring” (MMM) computer which utilizes ICM+ Cambridge software. A Study of Immune-Mediated Activation of Astrocytes in Healthy Volunteers Rochester, Minn. The purpose of this study is to characterize the astrocyte response to various inflammatory drivers in the presence of innate immune cells collected from healthy subjects. We will identify innate immune cell populations that contribute to astrocyte reactivity and elucidate the mechanisms responsible for altering the transcriptional and translational profile of astrocytes. Pre-operative Vs. Post-operative Radiosurgery For Metastatic Brain Tumors Rochester, Minn., Scottsdale/Phoenix, Ariz., Jacksonville, Fla. The purpose of this study is to determine whether there is an increase in the time of a first occurrence of either: local recurrence, leptomeningeal disease, or symptomatic radiation brain necrosis in patients with brain metastases who receive SRS prior to surgery as compared to patients who receive surgery prior to SRS. A Phase 3 Efficacy And Safety Study Of Pitolisant In Patients With Prader-Willi Syndrome Rochester, Minn. The purpose of this study is to evaluate the impact of pitolisant on Excessive daytime sleepiness in patients with Prader-Willi syndrome. Pagination Clinical studies PrevPrevious Page Go to page 55 Go to page 66 Go to page 77 Go to page 88 Go to page 99 NextNext Page Medical Professionals Neurology & Neurosurgery Clinical Trials